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Ligand · NGC

NGC · N-glycolyl-alpha-neuraminic acid

NGC, N-glycolyl-alpha-neuraminic acid (C11 H19 N O10, 325.3 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
NGC
Formula
C11 H19 N O10
Class
sugar
Structures
9
PDB entries
6

Binding sites

NGC in 9 structures; the first of them:

  • 5EQ3 · Crystal structure of the SrpA adhesin from Streptococcus sanguinis with a sialyl… · NGC C2 · binds PRO335, PRO337, ARG342, ALA343, GLN344, PHE345, THR346, ARG347 and 1 more
  • 6S2I · Anti-tumor antibody 14F7-derived scFv in complex with NeuGc Gm3 · NGC J3 · binds SER31, TYR32, TRP33, ASP52, SER96, PRO97, ARG98, TYR100D and 1 more
  • 7EE5 · Crystal structure of Neu5Gc bound PltC · NGC F3 · binds THR28, TYR29, VAL30, SER31, ILE64, ILE66, TYR103, VAL139
  • 7T1V · Crystal structure of an equine H7 hemagglutinin from A/equine/NY/49/73 (H7N7) in complex… · NGC G3 · binds TYR98, GLY134, GLU135, THR136, SER137, TRP153, LEU155, HIS183 and 4 more
  • 8U5O · The structure of the catalytic domain of NanI sialdase in complex with Neu5Gc · NGC A1701 · binds ARG1266, ILE1267, ARG1285, ASP1291, ILE1327, ASP1328, PHE1347, PHE1353 and 8 more
  • 6E7H · Crystal structure of H5 hemagglutinin mutant Y161A from A/VIET NAM/1203/2004 H5N1… · NGC I2 · binds TYR98, GLY134, VAL135, SER136, SER137, TRP153, ILE155, HIS183 and 5 more
  • 6S2I · Anti-tumor antibody 14F7-derived scfv in complex with neugc GM3 · NGC J3 · binds SER31, TYR32, TRP33, ASP52, PRO97, ARG98, TYR100D, ARG23
  • 7EE5 · Crystal structure of NEU5GC bound pltc · NGC F3 · binds THR28, TYR29, VAL30, SER31, ILE64, TYR103
  • 7T1V · Crystal structure of an equine H7 hemagglutinin from A/EQUINE/NY/49/73 (H7N7) in complex… · NGC G3 · binds TYR98, GLY134, GLU135, THR136, SER137, TRP153, LEU155, HIS183 and 4 more

Residues it binds most

TYR 19, ARG 16, GLY 13, SER 17, VAL 9, TRP 15, GLU 8, LEU 7, THR 12, ASP 9 (residue and the binding sites it lines).

Found with

  • GAL · beta-D-galactopyranose
  • BMA · beta-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CA · Calcium ion
  • BGC · beta-D-glucopyranose
  • GLC · alpha-D-glucopyranose
  • PG4 · Tetraethylene glycol
  • NA · Sodium ion
  • MBG · methyl beta-D-galactopyranoside
  • NO3 · Nitrate ion
  • ACT · Acetate ion

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