05E · 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate

Binding sites

05E in 5 structures; the first of them:

• 7WLD · Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53… · 05E T901 · binds HIS354, GLN355, PRO460, ASN461, PHE522, SER523
• 8IMY · Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate · 05E G1814 · binds HIS354, GLN355, ASP174, PRO460, ASP521, PHE522, SER523, THR220
• 8K9R · Cryo EM structure of the products-bound PGAP1(Bst1)-H443N from Chaetomium thermophilum · 05E A1503 · binds SER233, LYS235, GLN236, ARG238, GLU275
• 8K9T · Cryo-EM structure of the products-bound PGAP1(Bst1)-S327A from Chaetonium thermophilum · 05E A1504 · binds SER233, LYS235, GLN236, ARG238, GLU275
• 7WLD · Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53… · 05E T901 · binds HIS354, ASN461, PHE522

Residues it binds most

GLN 4, SER 4, HIS 3, PHE 3, ARG 2, ASN 2, ASP 1, GLU 2, LYS 2, PRO 2 (residue and the binding sites it lines).

Found with

• PA1 · 2-amino-2-deoxy-alpha-D-glucopyranose
• CLR · Cholesterol
• 80Y · 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate
• AJP · Digitonin
• Y01 · Cholesterol hemisuccinate
• CA · Calcium ion
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• 06O · [(2~{R})-1-hexadecanoyloxy-3-[[(1~{S},2~{R},3~{R}, 4~{S},5~{S},6~{R})-2-hexadecanoyloxy-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-propan-2-yl] (9~{Z},11~{Z})-octadeca-9, 11-dienoate
• BJR · (4S,7R)-7-[(hexadecanoyloxy)methyl]-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-3,5,8-trioxa-4lambda~5~-phosphahexacosan-1-aminium
• CDL · Cardiolipin
• DKB · [(2R)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoate
• P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine