MolNFT v2 · #211053 · protein
Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor
8GM4: “Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor”. X-ray diffraction at 2.12, 4 ligands (ADP, EKI, CA). MolNFT v2 #211053 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 8GM4
- Type
- protein
- Length
- 531 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.12
- Source
- Homo sapiens
- UniProt
- O00418, P0DP23
- Ligands
- ADP, EKI, CA, ZN
Structure
x-ray diffraction · resolution 2.12 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 462 | — | O00418 |
| B | — | protein | 69 | — | P0DP23 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A, B
- EKI · 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide · ligand · chains A
- CA · Calcium ion · metal · 2 copies · chains B
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- O00418 · AlphaFold monomer V2.0 prediction for eukaryotic elongation factor 2 kinase (O00418) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00418
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 8GM4 · PDBe 8GM4 · UniProt O00418 · UniProt P0DP23
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