UniProt O00418
Eukaryotic elongation factor 2 kinase (O00418)
Eukaryotic elongation factor 2 kinase (UniProt O00418), EC 2.7.11.20: 11 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O00418
- Protein
- Eukaryotic elongation factor 2 kinase
- EC
- 2.7.11.20
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 24 · 2 records with a druggable one
Structures
12 records of O00418 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5J8H | Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase | solution nmr | B | — | 2 (best 0.38) |
| 5J8H | Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase | solution nmr | B | — | — |
| 5KS5 | Structure of the C-terminal Helical Repeat Domain of Elongation Factor 2 Kinase | solution nmr | A | — | — |
| 5KS5 | Structure of the C-terminal helical repeat domain of elongation factor 2 kinase | solution nmr | A | — | — |
| 6NX4 | Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K) | solution nmr | A | — | — |
| 6NX4 | Structure of the C-terminal helical repeat domain of eukaryotic elongation factor 2 kinase (eef-2K) | solution nmr | A | — | — |
| 7SHQ | Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with… | x-ray diffraction | A | ZN, MG | — |
| 7SHQ | Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with… | x-ray diffraction | A | ZN, MG | — |
| 8FNY | Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. | x-ray diffraction | A, C | ATP, ADP, ZN, CA | 16 (best 0.80) |
| 8FO6 | Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. | x-ray diffraction | A | ZN, CA | 6 (best 0.74) |
| 8GM4 | Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive… | x-ray diffraction | A | ADP, EKI, ZN | — |
| O00418 | AlphaFold monomer V2.0 prediction for eukaryotic elongation factor 2 kinase (O00418) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8FO6 chain A against the predicted model O00418: TM-score 0.97, RMSD 1.48 Å
- 8FNY chain C against the predicted model O00418: TM-score 0.97, RMSD 1.55 Å
- 7SHQ chain A against the predicted model O00418: TM-score 0.96, RMSD 1.61 Å
- 7SHQ chain A against the predicted model O00418: TM-score 0.96, RMSD 1.61 Å
- 8FNY chain A against the predicted model O00418: TM-score 0.96, RMSD 1.70 Å
- 8GM4 chain A against the predicted model O00418: TM-score 0.95, RMSD 1.86 Å
- 6NX4 chain A against the predicted model O00418: TM-score 0.73, RMSD 2.83 Å
- 6NX4 chain A against the predicted model O00418: TM-score 0.73, RMSD 2.83 Å
- 5KS5 chain A against the predicted model O00418: TM-score 0.58, RMSD 1.83 Å
- 5KS5 chain A against the predicted model O00418: TM-score 0.58, RMSD 1.83 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.