UniProt P0DP23
Calmodulin-1 (P0DP23)
Calmodulin-1 (UniProt P0DP23): 119 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 163 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0DP23
- Protein
- Calmodulin-1
- Experimental structures
- 119
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 163 · 27 records with a druggable one
Structures
120 records of P0DP23 in the MolNFT archive: 119 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KUG | Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM… | solution nmr | A | — | — |
| 3EVV | Crystal Structure of Calcium bound dimeric GCAMP2 (#2) | x-ray diffraction | A | — | — |
| 3EVV | Crystal structure of calcium bound dimeric GCAMP2 (#2) | x-ray diffraction | A | — | — |
| 3O77 | The structure of Ca2+ Sensor (Case-16) | x-ray diffraction | A | — | — |
| 3O77 | The structure of CA2+ sensor (case-16) | x-ray diffraction | A | — | — |
| 3O78 | The structure of Ca2+ Sensor (Case-12) | x-ray diffraction | A, B | — | — |
| 3O78 | The structure of CA2+ sensor (case-12) | x-ray diffraction | A, B | — | — |
| 5OEO | Solution structure of the complex of TRPV5(655-725) with a calmodulin E32Q/E68Q double mutant | solution nmr | A | CA | — |
| 5V02 | A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA | x-ray diffraction | R | 657, CA | — |
| 5V02 | A positive allosteric modulator binding pocket in SK2 ion channels is shared by riluzole and cyppa | x-ray diffraction | R | 657, CA | — |
| 5V7X | Crystal structure of myosin 1B residues 1-728 with bound sulfate and calmodulin | x-ray diffraction | B | — | — |
| 5WBX | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | R | CA, AJY | — |
| 5WBX | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | R | CA, AJY | — |
| 5WC5 | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | R | CA, SO4, AJV | 1 (best 0.69) |
| 5WC5 | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | R | CA, SO4, AJV | — |
| 6B8L | Crystal structure of the APO/CAM:KV7.4 (KCNQ4) ab domain complex | x-ray diffraction | B, D, F, H | SO4 | — |
| 6B8M | Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak | x-ray diffraction | B, D, F, H | CA, SO4 | — |
| 6B8M | Crystal structure of the CA2+/CAM:KV7.4 (KCNQ4) ab domain complex, 1 mm CACL2 soak | x-ray diffraction | B, D, F, H | CA, SO4 | — |
| 6B8N | Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak | x-ray diffraction | B, D, F, H | CA, SO4 | 13 (best 0.75) |
| 6B8N | Crystal structure of the CA2+/CAM:KV7.4 (KCNQ4) ab domain complex, 10 um CACL2 soak | x-ray diffraction | B, D, F, H | CA, SO4 | — |
| 6B8P | Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex | x-ray diffraction | B, D, F, H | MG, SO4 | — |
| 6B8P | Crystal structure of the MG2+/CAM:KV7.4 (KCNQ4) ab domain complex | x-ray diffraction | B, D, F, H | MG, SO4 | — |
| 6B8Q | Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex | x-ray diffraction | B, D, F, H | MG | 13 (best 0.76) |
| 6B8Q | Crystal structure of the MG2+/CAM:KV7.5 (KCNQ5) ab domain complex | x-ray diffraction | B, D, F, H | MG | — |
| 6BUT | Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human… | solution nmr | A | — | 1 (best 0.52) |
| 6BUT | Solution structure of full-length apo mammalian calmodulin bound to the iq motif of the human… | solution nmr | A | — | — |
| 6CNM | Cryo-EM structure of the human SK4/CALMODULIN channel complex | electron microscopy | E, F, G, H | — | — |
| 6CNN | Cryo-EM structure of the human SK4/CALMODULIN channel complex in the CA2+ bound state I | electron microscopy | E, F, G, H | CA | — |
| 6CNO | Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II | electron microscopy | E, F, G, H | CA | 10 (best 0.84) |
| 6CNO | Cryo-EM structure of the human SK4/CALMODULIN channel complex in the CA2+ bound state II | electron microscopy | E, F, G, H | CA | — |
| 6DAD | 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex | x-ray diffraction | A, B | CA | 5 (best 0.58) |
| 6DAD | 1.65 ångström crystal structure of the N97I CA/CAM:CAV1.2 iq domain complex | x-ray diffraction | A, B | CA | — |
| 6DAE | 2.0 ångström crystal structure of the D95V CA/CAM:CAV1.2 iq domain complex | x-ray diffraction | A, B | CA | — |
| 6DAF | 2.4 ångström crystal structure of the F141L CA/CAM:CAV1.2 iq domain complex | x-ray diffraction | A, B | CA | — |
| 6DAH | 2.5 Angstrom crystal structure of the N97S CaM mutant | x-ray diffraction | A, B, C, D | CA | 5 (best 0.45) |
| 6DAH | 2.5 ångström crystal structure of the N97S cam mutant | x-ray diffraction | A, B, C, D | CA | — |
| 6E2F | Cryo-EM structure of human TRPV6 in complex with calmodulin | electron microscopy | E | CA | — |
| 6E2G | Cryo-EM structure of rat TRPV6 in complex with calmodulin | electron microscopy | E | CA | — |
| 6EEB | Calmodulin in complex with malbrancheamide | x-ray diffraction | A | J6P, CA, ZN | — |
| 6FEG | Solution structure of CAM/KV7.2-hab complex | solution nmr | B | CA | — |
| 6FEH | Solution Structure of CaM/Kv7.2-hAB Complex | solution nmr | B | CA | 6 (best 0.61) |
| 6FEH | Solution structure of CAM/KV7.2-hab complex | solution nmr | B | CA | — |
| 6GDK | Calcium bound form of human calmodulin mutant F141L | solution nmr | A | CA | — |
| 6GDL | Calmodulin mutant - F141L apo-form unstructured C-domain | solution nmr | A | — | — |
| 6HCS | Crystal structure of CaM-peptide complex containing AzF at position 108 | x-ray diffraction | A, C, E, G | CA | — |
| 6HCS | Crystal structure of cam-peptide complex containing azf at position 108 | x-ray diffraction | A, C, E, G | CA | — |
| 6HR1 | Crystal structure of the YFPnano fusion protein | x-ray diffraction | A, B | CA, NA | — |
| 6HR1 | Crystal structure of the yfpnano fusion protein | x-ray diffraction | A, B | CR2, CA, NA | — |
| 6JIY | Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset) | electron microscopy | C, F, I, L | CA | — |
| 6JV2 | Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset) | electron microscopy | B, D, F, H | CA | — |
| 6K4K | Crystal structure of sidj-cam binary complex at 2.71 a | x-ray diffraction | C, D | CA | — |
| 6K4L | Crystal structure of Se-labelled SidJ complex with CaM at 2.95 A | x-ray diffraction | C, D | CA | — |
| 6K4L | Crystal structure of se-labelled sidj complex with cam at 2.95 a | x-ray diffraction | C, D | CA | — |
| 6K4R | Crystal structure of SidJ-CaM-AMP ternary complex at 3.11 A | x-ray diffraction | C, D | CA | 9 (best 0.76) |
| 6K4R | Crystal structure of sidj-cam-AMP ternary complex at 3.11 a | x-ray diffraction | C, D | CA | — |
| 6M7H | Structure of calmodulin with KN93 | x-ray diffraction | A | KN9, CA | — |
| 6M7H | Structure of calmodulin with KN93 | x-ray diffraction | A | KN9, CA | — |
| 6MUD | Voltage-gated sodium channel NAV1.5 C-terminal domain in complex with CA2+/CALMODULIN | x-ray diffraction | A | CA | — |
| 6MUE | Voltage-gated sodium channel NaV1.4 IQ domain in complex with Ca2+/Calmodulin | x-ray diffraction | A | CA | — |
| 6MUE | Voltage-gated sodium channel NAV1.4 iq domain in complex with CA2+/CALMODULIN | x-ray diffraction | A | CA | — |
60 records more on the page itself.
Ligands
- CA · Calcium ion · in 83 records
- SO4 · Sulfate ion · in 10 records
- MG · Magnesium ion · in 7 records
- NA · Sodium ion · in 4 records
- ZN · Zinc ion · in 4 records
- 657 · 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine · in 2 records
- 85H · 1-[bis(4-chlorophenyl)methyl]-3-[(2~{R})-2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl) methoxy]ethyl]imidazole · in 2 records
- AJV · 7-fluoro-3-(hydroxyamino)-2H-indol-2-one · in 2 records
- AJY · (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one · in 2 records
- CL · Chloride ion · in 2 records
- KN9 · N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide · in 2 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- CR2 · {(4Z)-2-(aminomethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · in 1 record
- J6P · (5as,12as,13as)-8,9-dichloro-12,12-dimethyl-2,3,11,12, 12A,13-hexahydro-1H,5H,6H-5A,13A-(epiminomethano) indolizino[7,6-b]carbazol-14-one · in 1 record
- LMJ · (5as,12as,13as)-9-bromo-8-chloro-12,12-dimethyl-2,3,11, 12,12A,13-hexahydro-1H,5H,6H-5A,13A-(epiminomethano) indolizino[7,6-b]carbazol-14-one · in 1 record
Experiment against prediction
- 6HR1 chain B against the predicted model P42212: TM-score 0.57, RMSD 0.57 Å
- 6HR1 chain B against the predicted model P42212: TM-score 0.57, RMSD 0.57 Å
- 6HR1 chain A against the predicted model P42212: TM-score 0.55, RMSD 0.55 Å
- 6HR1 chain A against the predicted model P42212: TM-score 0.55, RMSD 0.55 Å
- 6PAW chain H against the predicted model P0DP23: TM-score 0.92, RMSD 0.80 Å
- 6PAW chain G against the predicted model P0DP23: TM-score 0.91, RMSD 0.88 Å
- 8GM4 chain B against the predicted model P0DP23: TM-score 0.90, RMSD 1.03 Å
- 6PAW chain C against the predicted model P0DP23: TM-score 0.83, RMSD 1.81 Å
- 2KUG chain A against the predicted model P0DP23: TM-score 0.79, RMSD 2.25 Å
- 6YNS chain L against the predicted model P0DP23: TM-score 0.66, RMSD 3.44 Å
Elsewhere
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