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Ligand · HLT

HLT · 2-bromo-2-chloro-1,1,1-trifluoroethane

HLT, 2-bromo-2-chloro-1,1,1-trifluoroethane (C2 H Br Cl F3, 197.4 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
HLT
Formula
C2 H Br Cl F3
Class
ligand
Structures
12
PDB entries
6

Binding sites

HLT in 12 structures; the first of them:

  • 1E7B · Crystal structure of human serum albumin complexed with the general anesthetic halothane · HLT A4001 · binds ARG209, LYS212, ALA213, VAL216, ASP324, LEU327, GLY328, LEU331
  • 1E7C · HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID and the general anesthetic halothane · HLT A4001 · binds ARG209, LYS212, ALA213, ASP324, VAL325, LEU327, GLY328, LEU331
  • 1XZ1 · Complex of halothane with apoferritin · HLT A2001 · binds LEU24, SER27, TYR28, LEU81
  • 2JST · Four-Alpha-Helix Bundle with Designed Anesthetic Binding Pockets II: Halothane Effects on… · HLT A101 · binds TRP15, LEU18, ALA19, ALA44, GLU14, TRP15, LEU18, ALA19 and 1 more
  • 2KUG · Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of… · HLT A149 · binds MET36, LEU39, MET51, MET71, LYS75
  • 2KUH · Halothane binds to druggable sites in calcium-calmodulin: Solution structure of… · HLT A150 · binds LEU105, MET109, LEU116, MET124, GLU127, MET144
  • 1E7B · Crystal structure of human serum albumin complexed with the general anesthetic halothane · HLT A4001 · binds ARG209, LYS212, ALA213, VAL216, ASP324, LEU327, GLY328, LEU331
  • 1E7C · Human serum albumin complexed with myristic acid and the general anesthetic halothane · HLT A4001 · binds ARG209, LYS212, ALA213, ASP324, VAL325, LEU327, GLY328, LEU331
  • 1XZ1 · Complex of halothane with apoferritin · HLT A2001 · binds LEU24, SER27, TYR28, LEU81
  • 2JST · Four-alpha-helix bundle with designed anesthetic binding pockets II: halothane effects on… · HLT A101 · binds TRP15, LEU18, ALA19, ALA44, GLU14, TRP15, LEU18, ALA19 and 1 more
  • 2KUG · Halothane binds to druggable sites in calcium-calmodulin: solution structure of… · HLT A149 · binds MET36, LEU39, MET51, MET71, LYS75
  • 2KUH · Halothane binds to druggable sites in calcium-calmodulin: solution structure of… · HLT A150 · binds LEU105, MET109, LEU116, MET124, GLU127, MET144

Residues it binds most

LEU 32, ALA 26, LYS 16, VAL 14, ARG 16, MET 4, ASP 10, GLU 10, GLY 10, ILE 8 (residue and the binding sites it lines).

Found with

  • CA · Calcium ion
  • MYR · Myristic acid
  • CD · Cadmium ion

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