MolNFT v2 · #200703 · protein
GPR119-Gs-APD668 complex
7XZ6: “GPR119-Gs-APD668 complex”. Electron microscopy at 2.8, 1 ligand (I7J). MolNFT v2 #200703 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7XZ6
- Type
- protein
- Length
- 1,052 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.8
- Source
- Escherichia coli; Homo sapiens; Lama glama
- UniProt
- P62873, P59768, P0ABE7, Q8TDV5
- Ligands
- I7J
Structure
electron microscopy · resolution 2.8 · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 237 | — | — |
| B | — | protein | 338 | — | P62873 |
| G | — | protein | 57 | — | P59768 |
| N | — | protein | 128 | — | — |
| R | — | protein | 292 | — | P0ABE7, Q8TDV5 |
Ligands and binding sites
- I7J · Propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl) pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7XZ6 · GPR119-gs-APD668 complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.93
- Q8TDV5 · AlphaFold monomer V2.0 prediction for glucose-dependent insulinotropic receptor (Q8TDV5) · a predicted model of the same protein · chain R against A, TM-score 0.92
- P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain R against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P0ABE7
- Every structure of UniProt Q8TDV5
- Elsewhere: RCSB PDB 7XZ6 · PDBe 7XZ6 · UniProt P62873 · UniProt P59768 · UniProt P0ABE7 · UniProt Q8TDV5
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