UniProt Q8TDV5
Glucose-dependent insulinotropic receptor (Q8TDV5)
Glucose-dependent insulinotropic receptor (UniProt Q8TDV5): 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8TDV5
- Protein
- Glucose-dependent insulinotropic receptor
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 26 · 5 records with a druggable one
Structures
9 records of Q8TDV5 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7WCN | Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453 | electron microscopy | R | 8WL | 7 (best 0.78) |
| 7XZ5 | GPR119-Gs-LPC complex | electron microscopy | R | LSC | 5 (best 0.76) |
| 7XZ5 | GPR119-gs-lpc complex | electron microscopy | R | LSC | — |
| 7XZ6 | GPR119-Gs-APD668 complex | electron microscopy | R | I7J | — |
| 7XZ6 | GPR119-gs-APD668 complex | electron microscopy | R | I7J | — |
| 8VHF | Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982 | electron microscopy | R | 8VP | 8 (best 0.81) |
| 8ZR5 | Cryo-EM Structure of GPR119-Gs-Firuglipel complex | electron microscopy | C | A1D8M | 3 (best 0.77) |
| 8ZRK | Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263 | electron microscopy | R | A1D8Y | 3 (best 0.77) |
| Q8TDV5 | AlphaFold monomer V2.0 prediction for glucose-dependent insulinotropic receptor (Q8TDV5) | predicted | A | — | — |
Ligands
- I7J · Propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl) pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate · in 2 records
- LSC · (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide · in 2 records
- 8VP · 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole · in 1 record
- 8WL · N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine · in 1 record
- A1D8M · 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide · in 1 record
- A1D8Y · Gsk-1292263 · in 1 record
Experiment against prediction
- 8ZRK chain R against the predicted model Q8TDV5: TM-score 0.93, RMSD 2.02 Å
- 7WCN chain R against the predicted model Q8TDV5: TM-score 0.92, RMSD 2.21 Å
- 7XZ6 chain R against the predicted model Q8TDV5: TM-score 0.92, RMSD 2.24 Å
- 7XZ6 chain R against the predicted model Q8TDV5: TM-score 0.92, RMSD 2.24 Å
- 7XZ5 chain R against the predicted model Q8TDV5: TM-score 0.92, RMSD 2.14 Å
- 7XZ5 chain R against the predicted model Q8TDV5: TM-score 0.92, RMSD 2.14 Å
- 8ZR5 chain C against the predicted model Q8TDV5: TM-score 0.92, RMSD 2.22 Å
- 8VHF chain R against the predicted model Q8TDV5: TM-score 0.90, RMSD 2.40 Å
- 7XZ6 chain R against the predicted model P0ABE7: TM-score 0.26, RMSD 4.42 Å
- 7XZ6 chain R against the predicted model P0ABE7: TM-score 0.26, RMSD 4.42 Å
Elsewhere
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