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Ligand · 8VP

8VP · 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole

8VP, 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (C22 H24 N8 O S, 448.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with…

Component
8VP
Formula
C22 H24 N8 O S
Class
ligand
Structures
2
PDB entries
2

Binding sites

8VP in 2 structures; the first of them:

  • 7WCM · Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982 · 8VP R401 · binds PHE7, LEU61, GLN65, MET82, VAL85, THR86, ALA89, ALA90 and 15 more
  • 8VHF · Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982 · 8VP R601 · binds PHE7, LEU61, GLN65, MET82, VAL85, THR86, ALA89, ALA90 and 14 more

Residues it binds most

PHE 2, LEU 2, VAL 2, ALA 2, TRP 2, GLN 2, GLU 2, GLY 2, MET 2, SER 2 (residue and the binding sites it lines).

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