MolNFT v2 · #172027 · protein + DNA
Structure of human cGAS (K394E) bound to the nucleosome
6Y5D: “Structure of human cGAS (K394E) bound to the nucleosome”. Electron microscopy at 4.1, 2 ligands (PTD, ZN). MolNFT v2 #172027 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Y5D
- Type
- protein + DNA
- Length
- 2,830 residues
- Chains
- 22
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 4.1
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- UniProt
- Q71DI3, P62805, Q6FI13, O60814, Q8N884
- Ligands
- PTD, ZN
Structure
electron microscopy · resolution 4.1 · 16 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, M | — | protein | 96 | — | Q71DI3 |
| B | — | protein | 81 | — | P62805 |
| C | — | protein | 107 | — | Q6FI13 |
| D, T | — | protein | 93 | — | O60814 |
| F | — | protein | 83 | — | P62805 |
| G | — | protein | 108 | — | Q6FI13 |
| H | — | protein | 94 | — | O60814 |
| I, U | — | dna | 153 | — | — |
| J, V | — | dna | 153 | — | — |
| K, L | — | protein | 362 | — | Q8N884 |
| N | — | protein | 79 | — | P62805 |
| O | — | protein | 105 | — | Q6FI13 |
| P | — | protein | 90 | — | O60814 |
| Q | — | protein | 94 | — | Q71DI3 |
| R | — | protein | 77 | — | P62805 |
| S | — | protein | 102 | — | Q6FI13 |
Ligands and binding sites
- PTD · Pentanedial · ligand · 9 copies · chains A, B, C, G, K, D, H, M, N, O, S, L, P
- ZN · Zinc ion · metal · 2 copies · chains K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6Y5D · Structure of human cgas (K394E) bound to the nucleosome · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71DI3
- Every structure of UniProt P62805
- Every structure of UniProt Q6FI13
- Every structure of UniProt O60814
- Every structure of UniProt Q8N884
- Elsewhere: RCSB PDB 6Y5D · PDBe 6Y5D · UniProt Q71DI3 · UniProt P62805 · UniProt Q6FI13 · UniProt O60814 · UniProt Q8N884
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