MolNFT v2 · #152649 · protein
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38.
6HUK: “CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody…”. Electron microscopy at 3.69, 5 ligands (H0Z, PIO, NAG). MolNFT v2 #152649 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6HUK
- Type
- protein
- Length
- 1,815 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.69
- Source
- Bos taurus; Homo sapiens; Lama glama
- UniProt
- P08219, P14867, P28472, P18507
- Ligands
- H0Z, PIO, NAG, MAN, BMA
Structure
electron microscopy · resolution 3.69 · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 347 | — | P08219, P14867 |
| B | — | protein | 336 | — | P28472 |
| C | — | protein | 330 | — | P18507 |
| D | — | protein | 347 | — | P08219, P14867 |
| E | — | protein | 334 | — | P28472 |
| G | — | protein | 121 | — | — |
Ligands and binding sites
- H0Z · bicuculline methochloride · ligand · 2 copies · chains A, B, D, E
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · ligand · 2 copies · chains A, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 14 copies · chains A, B, C, D, E
- MAN · alpha-D-mannopyranose · sugar · 12 copies · chains C, D, B, A, E
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains C, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6HUK · Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P14867 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-1… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P08219 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-1… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P18507 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit gamma-2… · a predicted model of the same protein · chain C against A, TM-score 0.99
- P28472 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-3… · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08219
- Every structure of UniProt P14867
- Every structure of UniProt P28472
- Every structure of UniProt P18507
- Elsewhere: RCSB PDB 6HUK · PDBe 6HUK · UniProt P08219 · UniProt P14867 · UniProt P28472 · UniProt P18507
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