UniProt P08219
P08219
P08219 (UniProt P08219): 9 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08219
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 8
Structures
10 records of P08219 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6HUG | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and… | electron microscopy | A, D | NAG, MAN, PIO, RI5 | — |
| 6HUG | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with picrotoxin and… | electron microscopy | A, D | NAG, MAN, PIO, RI5 | — |
| 6HUJ | CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with… | electron microscopy | A, D | NAG, MAN, PIO, RI5, ABU | — |
| 6HUJ | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | A, D | NAG, MAN, PIO, RI5, ABU | — |
| 6HUK | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and… | electron microscopy | A, D | NAG, MAN, H0Z, PIO | — |
| 6HUK | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with bicuculline and… | electron microscopy | A, D | NAG, MAN, H0Z, PIO | — |
| 6HUO | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | A, D | NAG, MAN, ABU, PIO, 08H | — |
| 6HUP | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam… | electron microscopy | A, D | NAG, MAN, PIO, ABU, DZP | — |
| 6HUP | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with diazepam… | electron microscopy | A, D | NAG, MAN, PIO, ABU, DZP | — |
| P08219 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-1 (P08219) | predicted | A | — | — |
Ligands
- MAN · alpha-D-mannopyranose · in 9 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 9 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 9 records
- ABU · Gamma-amino-butanoic acid · in 5 records
- RI5 · (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione · in 4 records
- DZP · 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one · in 2 records
- H0Z · bicuculline methochloride · in 2 records
- 08H · 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-A][1, 4]benzodiazepine · in 1 record
Experiment against prediction
- 6HUJ chain A against the predicted model P14867: TM-score 0.99, RMSD 0.51 Å
- 6HUJ chain A against the predicted model P14867: TM-score 0.99, RMSD 0.51 Å
- 6HUJ chain A against the predicted model P08219: TM-score 0.99, RMSD 0.55 Å
- 6HUJ chain A against the predicted model P08219: TM-score 0.99, RMSD 0.55 Å
- 6HUK chain A against the predicted model P14867: TM-score 0.99, RMSD 0.57 Å
- 6HUK chain A against the predicted model P14867: TM-score 0.99, RMSD 0.57 Å
- 6HUJ chain D against the predicted model P14867: TM-score 0.99, RMSD 0.64 Å
- 6HUJ chain D against the predicted model P14867: TM-score 0.99, RMSD 0.64 Å
- 6HUK chain D against the predicted model P14867: TM-score 0.99, RMSD 0.67 Å
- 6HUK chain D against the predicted model P14867: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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