UniProt P18507
Gamma-aminobutyric acid receptor subunit gamma-2 (P18507)
Gamma-aminobutyric acid receptor subunit gamma-2 (UniProt P18507): 42 experimental structures and 1 predicted model on GenesisL1, 23 ligands bound, 198 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P18507
- Protein
- Gamma-aminobutyric acid receptor subunit gamma-2
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 23
- Pockets
- 198 · 21 records with a druggable one
Structures
43 records of P18507 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6D6U | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | E | BMA, MAN, Y01, FYP | 11 (best 0.86) |
| 6D6U | Human GABA-a receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | E | BMA, MAN, Y01, FYP | — |
| 6HUG | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and… | electron microscopy | C | BMA, MAN, NAG, RI5 | — |
| 6HUG | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with picrotoxin and… | electron microscopy | C | BMA, MAN, NAG, RI5 | — |
| 6HUJ | CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with… | electron microscopy | C | BMA, MAN, NAG, RI5 | — |
| 6HUJ | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | C | BMA, MAN, NAG, RI5 | — |
| 6HUK | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and… | electron microscopy | C | BMA, MAN, NAG | — |
| 6HUK | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with bicuculline and… | electron microscopy | C | BMA, MAN, NAG | — |
| 6HUO | CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with… | electron microscopy | C | BMA, MAN, NAG, 08H | 10 (best 0.85) |
| 6HUO | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | C | BMA, MAN, NAG, 08H | — |
| 6HUP | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam… | electron microscopy | C | BMA, MAN, NAG, DZP | — |
| 6HUP | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with diazepam… | electron microscopy | C | BMA, MAN, NAG, DZP | — |
| 6I53 | Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with… | electron microscopy | C | BMA, MAN, NAG | — |
| 6I53 | Cryo-EM structure of the human synaptic ALPHA1-BETA3-GAMMA2 gabaa receptor in complex with… | electron microscopy | C | BMA, MAN, NAG | — |
| 6X3S | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide | electron microscopy | E | BMA, MAN, NAG | 9 (best 0.80) |
| 6X3S | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with bicuculline methbromide | electron microscopy | E | BMA, MAN, NAG | — |
| 6X3T | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol | electron microscopy | E | BMA, MAN, NAG | 9 (best 0.84) |
| 6X3T | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus propofol | electron microscopy | E | BMA, MAN, NAG | — |
| 6X3U | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil | electron microscopy | E | BMA, MAN, NAG, FYP | 9 (best 0.84) |
| 6X3U | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus flumazenil | electron microscopy | E | BMA, MAN, NAG, FYP | — |
| 6X3V | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate | electron microscopy | E | BMA, MAN, NAG | 9 (best 0.87) |
| 6X3V | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus etomidate | electron microscopy | E | BMA, MAN, NAG | — |
| 6X3W | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital | electron microscopy | E | BMA, MAN, NAG, UQA | 8 (best 0.83) |
| 6X3W | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus phenobarbital | electron microscopy | E | BMA, MAN, NAG, UQA | — |
| 6X3X | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam | electron microscopy | E | BMA, MAN, NAG, DZP | 8 (best 0.87) |
| 6X3X | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus diazepam | electron microscopy | E | BMA, MAN, NAG, DZP | — |
| 6X3Z | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA | electron microscopy | E | BMA, MAN, NAG | 8 (best 0.85) |
| 6X3Z | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA | electron microscopy | E | BMA, MAN, NAG | — |
| 6X40 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin | electron microscopy | E | BMA, MAN, NAG, RI5 | 9 (best 0.85) |
| 6X40 | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus picrotoxin | electron microscopy | E | BMA, MAN, NAG, RI5 | — |
| 7T0W | Complex of GABA-A synaptic receptor with autoimmune antibody Fab115 | electron microscopy | E | NAG, BMA, MAN | 12 (best 0.75) |
| 7T0Z | Complex of GABA-A synaptic receptor with autoimmune antibody Fab175 | electron microscopy | E | NAG, BMA, MAN | 8 (best 0.84) |
| 8BHG | GABA-A receptor a5 heteromer - a5V2 - Bretazenil | x-ray diffraction | B | QMU, NO3, NAG | 11 (best 0.79) |
| 8DD2 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem | electron microscopy | E | BMA, MAN, NAG, R5R | 11 (best 0.86) |
| 8DD2 | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus zolpidem | electron microscopy | E | BMA, MAN, NAG, R5R | — |
| 8DD3 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM | electron microscopy | E | BMA, MAN, NAG, R63 | 10 (best 0.86) |
| 8SGO | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate | electron microscopy | E | BMA, MAN, NAG, PTY, A8W | 9 (best 0.83) |
| 8SI9 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone | electron microscopy | E | BMA, MAN, NAG | 10 (best 0.82) |
| 8SID | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus dehydroepiandrosterone… | electron microscopy | E | BMA, MAN, NAG, ZWY, PTY | 8 (best 0.84) |
| 8VQY | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone | electron microscopy | E | BMA, MAN, NAG, Q3G, A1ADG | 9 (best 0.86) |
| 8VRN | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ | electron microscopy | E | BMA, MAN, NAG, Q3G | 10 (best 0.87) |
| 9EQG | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin | electron microscopy | C | BMA, MAN, D10, PLM, NAG, R16 | 10 (best 0.84) |
| P18507 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit gamma-2 (P18507) | predicted | A | — | — |
Ligands
- BMA · beta-D-mannopyranose · in 41 records
- MAN · alpha-D-mannopyranose · in 41 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 40 records
- RI5 · (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione · in 6 records
- DZP · 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one · in 4 records
- FYP · Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1, 5-a][1,4]benzodiazepine-3-carboxylate · in 4 records
- 08H · 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-A][1, 4]benzodiazepine · in 2 records
- PTY · Phosphatidylethanolamine · in 2 records
- Q3G · O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy) propoxy](hydroxy)phosphoryl]-D-serine · in 2 records
- R5R · Zolpidem · in 2 records
- UQA · 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- A1ADG · 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one · in 1 record
- A1H6W · Puerarin · in 1 record
- A8W · Pregnenolone sulfate · in 1 record
- CL · Chloride ion · in 1 record
- D10 · Decane · in 1 record
- NO3 · Nitrate ion · in 1 record
- PLM · Palmitic acid · in 1 record
- QMU · Bretazenil · in 1 record
- R16 · Hexadecane · in 1 record
- R63 · methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate · in 1 record
- ZWY · 17-oxoandrost-5-en-3beta-yl hydrogen sulfate · in 1 record
Experiment against prediction
- 6HUJ chain C against the predicted model P18507: TM-score 0.99, RMSD 0.57 Å
- 6HUJ chain C against the predicted model P18507: TM-score 0.99, RMSD 0.57 Å
- 6I53 chain C against the predicted model P18507: TM-score 0.99, RMSD 0.60 Å
- 6I53 chain C against the predicted model P18507: TM-score 0.99, RMSD 0.60 Å
- 6HUO chain C against the predicted model P18507: TM-score 0.99, RMSD 0.62 Å
- 6HUO chain C against the predicted model P18507: TM-score 0.99, RMSD 0.62 Å
- 6HUP chain C against the predicted model P18507: TM-score 0.99, RMSD 0.69 Å
- 6HUP chain C against the predicted model P18507: TM-score 0.99, RMSD 0.69 Å
- 6HUG chain C against the predicted model P18507: TM-score 0.99, RMSD 0.71 Å
- 6HUG chain C against the predicted model P18507: TM-score 0.99, RMSD 0.71 Å
Elsewhere
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