MolNFT v1 · #146080 · protein
Human GABA-a receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA and flumazenil, conformation a
6D6U: “Human GABA-a receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA and flumazenil, conformation a”. Electron microscopy, 6 ligands (Y01, ABU, FYP). MolNFT v1 #146080 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6D6U
- Type
- protein
- Length
- 2,106 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P47870, P14867, P18507
- Ligands
- Y01, ABU, FYP, NAG, MAN, BMA
Structure
electron microscopy · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 333 | — | P47870 |
| B | — | protein | 336 | — | P14867 |
| D | — | protein | 338 | — | P14867 |
| E | — | protein | 322 | — | P18507 |
| I, L | — | protein | 106 | — | — |
| J | — | protein | 116 | — | — |
| K | — | protein | 116 | — | — |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 12 copies · chains A, E, B, C, D
- ABU · Gamma-amino-butanoic acid · ligand · 2 copies · chains A, B, C, D
- FYP · Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1, 5-a][1,4]benzodiazepine-3-carboxylate · ligand · chains D, E
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 10 copies · chains A, B, C, D
- MAN · alpha-D-mannopyranose · sugar · 7 copies · chains E, B, C
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6D6U · Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil… · the same entry in another collection · chain K against K, TM-score 1.00
- P14867 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-1… · a predicted model of the same protein · chain B against A, TM-score 0.97
- P47870 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47870
- Every structure of UniProt P14867
- Every structure of UniProt P18507
- Elsewhere: RCSB PDB 6D6U · PDBe 6D6U · UniProt P47870 · UniProt P14867 · UniProt P18507
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