UniProt P47870
Gamma-aminobutyric acid receptor subunit beta-2 (P47870)
Gamma-aminobutyric acid receptor subunit beta-2 (UniProt P47870): 18 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 98 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P47870
- Protein
- Gamma-aminobutyric acid receptor subunit beta-2
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 98 · 7 records with a druggable one
Structures
19 records of P47870 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6D6T | Human GABA-a receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | A, C | NAG, ABU, Y01 | — |
| 6D6U | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | A, C | NAG, MAN, ABU, Y01 | 13 (best 0.86) |
| 6D6U | Human GABA-a receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | A, C | NAG, MAN, ABU, Y01 | — |
| 6X3S | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide | electron microscopy | A, C | NAG, J94, MAN | 13 (best 0.80) |
| 6X3S | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with bicuculline methbromide | electron microscopy | A, C | NAG, J94 | — |
| 6X3T | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus propofol | electron microscopy | A, C | NAG, ABU, PFL | — |
| 6X3U | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil | electron microscopy | A, C | NAG, ABU | 15 (best 0.84) |
| 6X3U | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus flumazenil | electron microscopy | A, C | NAG, ABU | — |
| 6X3V | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus etomidate | electron microscopy | A, C | NAG, ABU, V8D | — |
| 6X3W | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus phenobarbital | electron microscopy | A, C | NAG, MAN, ABU, UQA | — |
| 6X3X | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus diazepam | electron microscopy | A, C | NAG, MAN, ABU, DZP | — |
| 6X3Z | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA | electron microscopy | A, C | NAG, MAN, ABU | — |
| 6X40 | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus picrotoxin | electron microscopy | A, C | NAG, MAN, ABU, RI5 | — |
| 7T0Z | Complex of GABA-A synaptic receptor with autoimmune antibody Fab175 | electron microscopy | A, C | NAG, MAN, ABU | 13 (best 0.84) |
| 8DD2 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem | electron microscopy | A, C | NAG, MAN, R5R, ABU | 14 (best 0.86) |
| 8DD2 | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus zolpidem | electron microscopy | A, C | NAG, MAN, R5R, ABU | — |
| 8SI9 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone | electron microscopy | A, C | NAG, MAN, Y4B, ABU | 15 (best 0.82) |
| 8VQY | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone | electron microscopy | A, C | NAG, MAN, ABU, A1ADG, PTY, Q3G | 15 (best 0.86) |
| P47870 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-2 (P47870) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 18 records
- ABU · Gamma-amino-butanoic acid · in 16 records
- MAN · alpha-D-mannopyranose · in 12 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- J94 · (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1, 3]dioxolo[4,5-g]isoquinolin-6-ium · in 2 records
- R5R · Zolpidem · in 2 records
- A1ADG · 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one · in 1 record
- DZP · 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one · in 1 record
- PFL · 2,6-bis(1-methylethyl)phenol · in 1 record
- PTY · Phosphatidylethanolamine · in 1 record
- Q3G · O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy) propoxy](hydroxy)phosphoryl]-D-serine · in 1 record
- RI5 · (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione · in 1 record
- UQA · 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione · in 1 record
- V8D · Ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate · in 1 record
- Y4B · allopregnanolone · in 1 record
Experiment against prediction
- 6X3V chain C against the predicted model P47870: TM-score 0.99, RMSD 0.67 Å
- 6X3V chain A against the predicted model P47870: TM-score 0.99, RMSD 0.66 Å
- 8VQY chain C against the predicted model P47870: TM-score 0.99, RMSD 0.69 Å
- 8VQY chain A against the predicted model P47870: TM-score 0.99, RMSD 0.68 Å
- 8SI9 chain C against the predicted model P47870: TM-score 0.99, RMSD 0.70 Å
- 6X3X chain C against the predicted model P47870: TM-score 0.99, RMSD 0.71 Å
- 6X3X chain A against the predicted model P47870: TM-score 0.99, RMSD 0.69 Å
- 8DD2 chain C against the predicted model P47870: TM-score 0.99, RMSD 0.70 Å
- 8DD2 chain C against the predicted model P47870: TM-score 0.99, RMSD 0.70 Å
- 6X3Z chain C against the predicted model P47870: TM-score 0.99, RMSD 0.74 Å
Elsewhere
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