UniProt P28472
Gamma-aminobutyric acid receptor subunit beta-3 (P28472)
Gamma-aminobutyric acid receptor subunit beta-3 (UniProt P28472): 37 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 165 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P28472
- Protein
- Gamma-aminobutyric acid receptor subunit beta-3
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 165 · 9 records with a druggable one
Structures
38 records of P28472 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4COF | Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer | x-ray diffraction | A, B, C, D, E | — | — |
| 4COF | Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-BETA3 homopentamer | x-ray diffraction | A, B, C, D, E | — | — |
| 5O8F | Structure of a chimaeric BETA3-ALPHA5 gabaa receptor in complex with nanobody NB25 and pregnanolone | x-ray diffraction | A, B, C, D, E | NAG, BMA, MAN, P9N | — |
| 5OJM | Structure of a chimaeric BETA3-ALPHA5 gabaa receptor in complex with nanobody NB25 | x-ray diffraction | A, B, C, D, E | NAG, BMA, MAN | — |
| 6A96 | Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 | electron microscopy | B, E, C, D | NAG, BMA, MAN, ABU | 18 (best 0.84) |
| 6A96 | Cryo-EM structure of the human ALPHA5BETA3 gabaa receptor in complex with GABA and NB25 | electron microscopy | B, E, C, D | NAG, BMA, MAN, ABU | — |
| 6HUG | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and… | electron microscopy | B, E | NAG, BMA, MAN, RI5 | — |
| 6HUG | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with picrotoxin and… | electron microscopy | B, E | NAG, BMA, MAN, RI5 | — |
| 6HUJ | CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with… | electron microscopy | B, E | NAG, BMA, MAN, RI5, ABU | — |
| 6HUJ | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | B, E | NAG, BMA, MAN, RI5, ABU | — |
| 6HUK | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and… | electron microscopy | B, E | NAG, MAN, BMA, H0Z | — |
| 6HUK | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with bicuculline and… | electron microscopy | B, E | NAG, MAN, BMA, H0Z | — |
| 6HUO | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | B, E | NAG, BMA, MAN, ABU | — |
| 6HUP | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam… | electron microscopy | B, E | NAG, BMA, MAN, ABU, DZP | — |
| 6HUP | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with diazepam… | electron microscopy | B, E | NAG, BMA, MAN, ABU, DZP | — |
| 6I53 | Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with… | electron microscopy | E, B | NAG, BMA, MAN, POV | — |
| 6I53 | Cryo-EM structure of the human synaptic ALPHA1-BETA3-GAMMA2 gabaa receptor in complex with… | electron microscopy | E, B | NAG, BMA, MAN, POV | — |
| 6QFA | CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 | electron microscopy | B, C, D, E, A | NAG, BMA, MAN, HSM | 20 (best 0.83) |
| 6QFA | Cryoem structure of a BETA3K279T GABA(A)R homomer in complex with histamine and megabody MB25 | electron microscopy | B, C, D, E, A | NAG, BMA, MAN, HSM | — |
| 7A5V | Cryoem structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-BETA3 homopentamer, in… | electron microscopy | A | NAG, BMA, MAN, R16, D10, HSM | — |
| 7PC0 | GABA-A receptor bound by a-Cobratoxin | electron microscopy | B, C, E | NAG, BMA, MAN, HSM, ZN | 20 (best 0.78) |
| 7QN5 | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with… | electron microscopy | B, C, D | MAN, NAG, BMA, D10, CL | 15 (best 0.83) |
| 7QN5 | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with… | electron microscopy | B, C, D | MAN, NAG, BMA, D10, CL | — |
| 7QN6 | Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25 | electron microscopy | A, B, C, D | NAG, BMA, MAN | 20 (best 0.83) |
| 7QN6 | Cryo-EM structure of human full-length BETA3DELTA GABA(A)R in complex with nanobody NB25 | electron microscopy | A, B, C, D | NAG, BMA, MAN | — |
| 7QN7 | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with… | electron microscopy | B, C, D | MAN, NAG, BMA, D10, ABU, R16 | 17 (best 0.81) |
| 7QN7 | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with… | electron microscopy | B, C, D | MAN, NAG, BMA, D10, ABU, R16 | — |
| 7QN8 | Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody… | electron microscopy | A, B, C, D | NAG, BMA, MAN, HSM | 20 (best 0.83) |
| 7QN8 | Cryo-EM structure of human full-length BETA3DELTA GABA(A)R in complex with histamine and nanobody… | electron microscopy | A, B, C, D | NAG, BMA, MAN, HSM | — |
| 7QN9 | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with… | electron microscopy | B, C, D | NAG, BMA, MAN, HSM, R16, D10 | — |
| 7QNA | Cryo-EM structure of human full-length ALPHA4BETA3GAMMA2 GABA(A)R in complex with GABA and nanobody… | electron microscopy | B, D, E | NAG, BMA, ABU | — |
| 7QNB | Cryo-EM structure of human full-length beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25 | electron microscopy | B, D, E | NAG, BMA, MAN, ABU | 20 (best 0.81) |
| 7QNB | Cryo-EM structure of human full-length BETA3GAMMA2 GABA(A)R in complex with GABA and nanobody NB25 | electron microscopy | B, D, E | NAG, BMA, ABU | — |
| 7QNC | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with thip… | electron microscopy | B, C, D | MAN, NAG, BMA, D10, EI7, HSM | — |
| 7QND | Cryo-EM structure of human full-length extrasynaptic BETA3DELTA GABA(A)R in complex with thip… | electron microscopy | A, B, C, D | NAG, BMA, MAN, HSM, EI7 | — |
| 7QNE | Cryo-EM structure of human full-length synaptic ALPHA1BETA3GAMMA2 GABA(A)R in complex with… | electron microscopy | B, E | NAG, BMA, MAN, D10 | — |
| 9EQG | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin | electron microscopy | B, E | NAG, MAN, BMA, PGW, D10, PLM | 15 (best 0.84) |
| P28472 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-3 (P28472) | predicted | A | — | — |
Ligands
- BMA · beta-D-mannopyranose · in 35 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 35 records
- MAN · alpha-D-mannopyranose · in 33 records
- ABU · Gamma-amino-butanoic acid · in 13 records
- HSM · Histamine · in 11 records
- D10 · Decane · in 9 records
- R16 · Hexadecane · in 5 records
- RI5 · (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione · in 4 records
- CL · Chloride ion · in 3 records
- DZP · 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one · in 2 records
- EI7 · 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one · in 2 records
- H0Z · bicuculline methochloride · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- P9N · Pregnanolone · in 1 record
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 1 record
- PLM · Palmitic acid · in 1 record
- PX2 · 1,2-dilauroyl-sn-glycero-3-phosphate · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 6HUO chain B against the predicted model P28472: TM-score 0.99, RMSD 0.48 Å
- 6HUO chain E against the predicted model P28472: TM-score 0.99, RMSD 0.52 Å
- 6I53 chain B against the predicted model P28472: TM-score 0.99, RMSD 0.53 Å
- 6I53 chain B against the predicted model P28472: TM-score 0.99, RMSD 0.53 Å
- 6I53 chain E against the predicted model P28472: TM-score 0.99, RMSD 0.54 Å
- 6I53 chain E against the predicted model P28472: TM-score 0.99, RMSD 0.54 Å
- 6HUP chain B against the predicted model P28472: TM-score 0.99, RMSD 0.53 Å
- 6HUP chain B against the predicted model P28472: TM-score 0.99, RMSD 0.53 Å
- 6HUP chain E against the predicted model P28472: TM-score 0.99, RMSD 0.55 Å
- 6HUP chain E against the predicted model P28472: TM-score 0.99, RMSD 0.55 Å
Elsewhere
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