MolNFT v1 · #70272 · protein
Crystal structure of the fat mass and obesity associated (fto) protein reveals basis for its substrate specificity
3LFM · Protein fto: “Crystal structure of the fat mass and obesity associated (fto) protein reveals basis for its substrate…”. X-ray diffraction, 3 ligands (3DT, OGA, FE2), 2 pockets (best druggability 0.68). MolNFT v1 #70272 on GenesisL1…
- PDB
- 3LFM
- Type
- protein
- Length
- 420 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein fto
- EC
- 1.14.11.-
- UniProt
- Q9C0B1
- Ligands
- 3DT, OGA, FE2
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein fto (EC 1.14.11.-) | protein | 420 | 38% helix, 20% strand | Q9C0B1 |
Ligands and binding sites
- 3DT · 3-methylthymidine · ligand · chains A
- OGA · N-oxalylglycine · ligand · chains A
- FE2 · Fe (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.68 | 0.82 | 38 | 3DT, OGA, FE2 |
| 2 | 158 | 0.57 | 0.82 | 32 | empty |
Compared structures
- 3LFM · Crystal structure of the fat mass and obesity associated (FTO) protein reveals basis for… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9C0B1 · AlphaFold monomer V2.0 prediction for alpha-ketoglutarate-dependent dioxygenase fto… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C0B1
- Elsewhere: RCSB PDB 3LFM · PDBe 3LFM · UniProt Q9C0B1
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