Research workbench
Crystal structure of the fat mass and obesity associated (fto) protein reveals basis for its substrate specificity
Analyse Crystal structure of the fat mass and obesity associated (fto) protein reveals… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LFM
- Type
- protein
- Length
- 420 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein fto
- EC
- 1.14.11.-
- UniProt
- Q9C0B1
- Ligands
- 3DT, OGA, FE2
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein fto (EC 1.14.11.-) | protein | 420 | 38% helix, 20% strand | Q9C0B1 |
Ligands and binding sites
- 3DT · 3-methylthymidine · ligand · chains A
- OGA · N-oxalylglycine · ligand · chains A
- FE2 · Fe (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.68 | 0.82 | 38 | 3DT, OGA, FE2 |
| 2 | 158 | 0.57 | 0.82 | 32 | empty |
Compared structures
- 3LFM · Crystal structure of the fat mass and obesity associated (FTO) protein reveals basis for… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9C0B1 · AlphaFold monomer V2.0 prediction for alpha-ketoglutarate-dependent dioxygenase fto… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C0B1
- Elsewhere: RCSB PDB 3LFM · PDBe 3LFM · UniProt Q9C0B1
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