MolNFT v1 · #63613 · protein
Crystal structure of the cbc-importin alpha complex.
3FEX · Nuclear cap-binding protein subunit 1: “Crystal structure of the cbc-importin alpha complex.”. X-ray diffraction, 15 pockets (best druggability 0.79). MolNFT v1 #63613 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3FEX
- Type
- protein
- Length
- 1,259 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear cap-binding protein subunit 1; Nuclear cap-binding protein subunit 2; Importin…
- UniProt
- Q09161, P52298, P52292
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 64% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear cap-binding protein subunit 1 | protein | 756 | 66% helix, 1% strand | Q09161 |
| B | Nuclear cap-binding protein subunit 2 | protein | 80 | 29% helix, 31% strand | P52298 |
| C | Importin subunit alpha-2 | protein | 423 | 69% helix, 0% strand | P52292 |
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 736 | 0.79 | 0.83 | 55 | empty |
| 2 | 500 | 0.75 | 0.83 | 49 | empty |
| 3 | 197 | 0.63 | 0.83 | 30 | empty |
| 4 | 211 | 0.57 | 0.79 | 38 | empty |
| 5 | 228 | 0.51 | 0.76 | 39 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1472 Ų buried · 40 hydrogen bonds · protein-protein
- A–B · 1286 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 3FEX · Crystal structure of the CBC-importin alpha complex. · the same entry in another collection · chain A against A, TM-score 1.00
- P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain C against A, TM-score 0.98
- P52298 · AlphaFold monomer V2.0 prediction for nuclear cap-binding protein subunit 2 (P52298) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q09161 · AlphaFold monomer V2.0 prediction for nuclear cap-binding protein subunit 1 (Q09161) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09161
- Every structure of UniProt P52298
- Every structure of UniProt P52292
- Elsewhere: RCSB PDB 3FEX · PDBe 3FEX · UniProt Q09161 · UniProt P52298 · UniProt P52292
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