MolNFT v1 · #260012 · protein
AlphaFold monomer V2.0 prediction for nuclear cap-binding protein subunit 1 (Q09161)
Q09161: “AlphaFold monomer V2.0 prediction for nuclear cap-binding protein subunit 1 (Q09161)”. 11 pockets (best druggability 0.76). MolNFT v1 #260012 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q09161
- Type
- protein
- Length
- 790 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x362a6d063b1B7E1B6EfD3A9A7CA3612e3FE037AA
- Molecule
- Nuclear cap-binding protein subunit 1
- UniProt
- Q09161
- Pockets
- 11 · best druggability 0.76
Structure
1 distinct chain · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear cap-binding protein subunit 1 | protein | 790 | 67% helix, 1% strand | Q09161 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 539 | 0.76 | 0.83 | 52 | empty |
| 2 | 85 | 0.68 | 0.93 | 24 | empty |
| 3 | 211 | 0.63 | 0.82 | 29 | empty |
| 4 | 360 | 0.59 | 0.76 | 43 | empty |
| 5 | 115 | 0.43 | 0.77 | 22 | empty |
Compared structures
- 8SRR · Cryo-EM structure of the CBC-ALYREF complex · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 8BY6 · Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and… · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 8SUY · Cryo-EM structure of the human cap binding complex (CBC) · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 8PNT · Structure of the human nuclear cap-binding complex bound to PHAX and m7G-capped RNA · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 3FEY · Crystal structure of the cbc-importin alpha complex. · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 3FEY · Crystal structure of the CBC-importin alpha complex. · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 8PMP · Structure of the human nuclear cap-binding complex bound to ARS2[147-871] and m7GTP · an experimental structure of the same protein · chain A against A, TM-score 0.94
- 5OO6 · Complex of human nuclear cap-binding complex with ARS2 C-terminal peptide · an experimental structure of the same protein · chain A against D, TM-score 0.93
- 5OO6 · Complex of human nuclear cap-binding complex with ARS2 C-terminal peptide · an experimental structure of the same protein · chain A against D, TM-score 0.93
- 3FEX · Crystal structure of the CBC-importin alpha complex. · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 3FEX · Crystal structure of the cbc-importin alpha complex. · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 1H6K · nuclear Cap Binding Complex · an experimental structure of the same protein · chain A against C, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09161
- Elsewhere: UniProt Q09161 · AlphaFold DB Q09161
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