MolNFT v1 · #48983 · protein
The crystal structure of full length human gins complex
2Q9Q · DNA replication complex gins protein PSF2: “The crystal structure of full length human gins complex”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #48983 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2Q9Q
- Type
- protein
- Length
- 1,404 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA replication complex gins protein PSF2; Gins complex subunit 4; DNA replication…
- UniProt
- Q9Y248, Q9BRT9, Q14691, Q9BRX5
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 56% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | DNA replication complex gins protein PSF2 | protein | 175 | 54% helix, 13% strand | Q9Y248 |
| B, F | Gins complex subunit 4 | protein | 196 | 58% helix, 12% strand | Q9BRT9 |
| C, G | DNA replication complex gins protein PSF1 | protein | 145 | 67% helix, 0% strand | Q14691 |
| D, H | Gins complex subunit 3 | protein | 186 | 48% helix, 9% strand | Q9BRX5 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 996 | 0.84 | 0.85 | 104 | empty |
| 2 | 383 | 0.79 | 0.88 | 42 | empty |
| 3 | 301 | 0.75 | 0.87 | 56 | empty |
| 4 | 410 | 0.63 | 0.78 | 53 | empty |
| 5 | 189 | 0.57 | 0.80 | 38 | empty |
Interfaces
18 interfaces between chains.
- A–B · 2098 Ų buried · 27 hydrogen bonds · protein-protein
- E–F · 2080 Ų buried · 21 hydrogen bonds · protein-protein
- F–G · 1777 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 1763 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1664 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 2Q9Q · The crystal structure of full length human GINS complex · the same entry in another collection · chain H against H, TM-score 1.00
- Q9BRT9 · AlphaFold monomer V2.0 prediction for DNA replication complex gins protein SLD5 (Q9BRT9) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q9Y248 · AlphaFold monomer V2.0 prediction for DNA replication complex gins protein PSF2 (Q9Y248) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q14691 · AlphaFold monomer V2.0 prediction for DNA replication complex gins protein PSF1 (Q14691) · a predicted model of the same protein · chain C against A, TM-score 0.95
- Q9BRX5 · AlphaFold monomer V2.0 prediction for DNA replication complex gins protein PSF3 (Q9BRX5) · a predicted model of the same protein · chain D against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y248
- Every structure of UniProt Q9BRT9
- Every structure of UniProt Q14691
- Every structure of UniProt Q9BRX5
- Elsewhere: RCSB PDB 2Q9Q · PDBe 2Q9Q · UniProt Q9Y248 · UniProt Q9BRT9 · UniProt Q14691 · UniProt Q9BRX5
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