Cryo-EM structure of the L-054,264-bound human SSTR2-GI1 complex

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• 9FI · ~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl) cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7WIG · Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex · the same entry in another collection · chain S against S, TM-score 1.00
• P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P30874 · AlphaFold monomer V2.0 prediction for somatostatin receptor type 2 (P30874) · a predicted model of the same protein · chain R against A, TM-score 0.90
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.83
• P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.66

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P30874
• Every structure of UniProt P63096
• Every structure of UniProt P54311
• Every structure of UniProt P63212
• Elsewhere: RCSB PDB 7WIG · PDBe 7WIG · UniProt P30874 · UniProt P63096 · UniProt P54311 · UniProt P63212