MolNFT v1 · #187106 · protein
EX4-D-ala bound to the glucagon-like peptide-1 RECEPTOR/G protein complex (conformer 1)
7S1M · Guanine nucleotide-binding protein G(S) subunit alpha…: “EX4-D-ala bound to the glucagon-like peptide-1 RECEPTOR/G protein complex (conformer 1)”. Electron microscopy, 14 pockets (best druggability 0.82). MolNFT v1 #187106 on…
- PDB
- 7S1M
- Type
- protein
- Length
- 1,169 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P43220
- Pockets
- 14 · best druggability 0.82
Structure
electron microscopy · 6 distinct chains · 40% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 233 | 49% helix, 18% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 340 | 8% helix, 48% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 58 | 60% helix, 0% strand | P59768 |
| N | NB35 | protein | 128 | 7% helix, 44% strand | — |
| P | EX4-D-ala | protein | 29 | 93% helix, 0% strand | — |
| R | Glucagon-like peptide 1 receptor | protein | 381 | 69% helix, 4% strand | P43220 |
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 677 | 0.82 | 0.86 | 56 | empty |
| 2 | 897 | 0.76 | 0.80 | 65 | empty |
| 3 | 995 | 0.76 | 0.78 | 77 | empty |
| 4 | 536 | 0.70 | 0.80 | 68 | empty |
| 5 | 116 | 0.66 | 0.90 | 25 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2213 Ų buried · 25 hydrogen bonds · protein-protein
- P–R · 1674 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1496 Ų buried · 28 hydrogen bonds · protein-protein
- A–R · 1035 Ų buried · 10 hydrogen bonds · protein-protein
- A–N · 981 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 1 d-amino (disulfide, D-amino acid).
Compared structures
- 7S1M · Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 1) · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.93
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P43220
- Elsewhere: RCSB PDB 7S1M · PDBe 7S1M · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P43220
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