MolNFT v1 · #186876 · protein

Peptide-19 bound to the glucagon-like peptide-1 receptor (glp-1R)

7RTB · Guanine nucleotide-binding protein G(S) subunit alpha…: “Peptide-19 bound to the glucagon-like peptide-1 receptor (glp-1R)”. Electron microscopy, 19 pockets (best druggability 0.82). MolNFT v1 #186876 on GenesisL1: 3D structure…

PDB: 7RTB
Type: protein
Length: 1,169 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
UniProt: P63092, P62873, P59768, P43220
Pockets: 19 · best druggability 0.82

Structure

electron microscopy · 6 distinct chains · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide-binding protein G(S) subunit alpha isoforms short	protein	235	48% helix, 17% strand	P63092
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	338	7% helix, 47% strand	P62873
G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein	56	59% helix, 0% strand	P59768
N	NB35	protein	126	5% helix, 44% strand	—
R	Glucagon-like peptide 1 receptor	protein	384	67% helix, 4% strand	P43220
P	Peptide-19	protein	30	90% helix, 0% strand	—

Pockets

19 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	735	0.82	0.85	52	empty
2	1040	0.77	0.79	68	empty
3	950	0.76	0.78	74	empty
4	692	0.73	0.79	83	empty
5	362	0.70	0.83	51	empty

Interfaces

7 interfaces between chains.

B–G · 2222 Å² buried · 18 hydrogen bonds · protein-protein
A–B · 1504 Å² buried · 32 hydrogen bonds · protein-protein
R–P · 1247 Å² buried · 6 hydrogen bonds · protein-protein
A–R · 1034 Å² buried · 11 hydrogen bonds · protein-protein
A–N · 1018 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide, 2 modified (disulfide, nonstandard).

Compared structures

7RTB · Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R) · the same entry in another collection · chain P against P, TM-score 1.00
P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.93
P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63092
Every structure of UniProt P62873
Every structure of UniProt P59768
Every structure of UniProt P43220
Elsewhere: RCSB PDB 7RTB · PDBe 7RTB · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P43220

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