MolNFT v1 · #186539 · protein
Mycobacterial CIII2CIV2 supercomplex, telacebec (Q203) bound
7RH7: “Mycobacterial CIII2CIV2 supercomplex, telacebec (Q203) bound”. Electron microscopy, 12 ligands (CDL, 9YF, MQ9). MolNFT v1 #186539 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RH7
- Type
- protein
- Length
- 6,072 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- I7GFE1, I7GD63, A0R049, I7FPH7, I7FQK8, A0R1B5, A0QVH4, I7G2H6, I7FPH1, I7FGS8, I7GD61
- Ligands
- CDL, 9YF, MQ9, 9XX, PLM, HEA, 9Y0, HEC, HEM, HUU, FES, CU
Structure
electron microscopy · 12 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| W, c | — | protein | 158 | — | I7GFE1 |
| Q, K | — | protein | 312 | — | I7GD63 |
| R, L | — | protein | 552 | — | — |
| S, X | — | protein | 203 | — | A0R049 |
| T, Z | — | protein | 139 | — | I7FPH7 |
| U, a | — | protein | 79 | — | I7FQK8 |
| V, b | — | protein | 145 | — | A0R1B5 |
| P, J | — | protein | 92 | — | A0QVH4 |
| G, D | — | protein | 216 | — | I7G2H6 |
| O, I | — | protein | 223 | — | I7FPH1 |
| E, F | — | protein | 535 | — | I7FGS8 |
| Y, M | — | protein | 382 | — | I7GD61 |
Ligands and binding sites
- CDL · Cardiolipin · ligand · 16 copies · chains R, E, S, T, O, M, P, F, L, X, Z, I, Y, J
- 9YF · (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1r,2r,3r,4r, 5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate · ligand · 8 copies · chains T, O, E, W, R, P, Z, I, F, L, J, c, Y, M
- MQ9 · Menaquinone-9 · ligand · 6 copies · chains R, T, O, E, Y, M, L, Z, I, F
- 9XX · (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate · ligand · 4 copies · chains W, R, P, G, E, D, F, L, J, c
- PLM · Palmitic acid · ligand · 4 copies · chains W, R, P, G, E, J, D, F, L, c
- HEA · Heme-A · ligand · 4 copies · chains Q, R, K, L
- 9Y0 · (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate · ligand · 4 copies · chains R, S, T, W, Q, P, K, L, J, c, X, Z
- HEC · Heme C · ligand · 4 copies · chains W, Q, O, M, K, c, I, Y
- HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains E, F
- HUU · 6-chloranyl-2-ethyl-N-[[4-[4-[4-(trifluoromethyloxy) phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide · ligand · 2 copies · chains E, M, F, Y
- FES · Fe2/s2 (inorganic) cluster · ligand · 2 copies · chains Y, M
- CU · Copper (II) ion · metal · 6 copies · chains Q, R, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RH7 · Mycobacterial CIII2CIV2 supercomplex, Telacebec (Q203) bound · the same entry in another collection · chain W against W, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I7GFE1
- Every structure of UniProt I7GD63
- Every structure of UniProt A0R049
- Every structure of UniProt I7FPH7
- Every structure of UniProt I7FQK8
- Every structure of UniProt A0R1B5
- Every structure of UniProt A0QVH4
- Every structure of UniProt I7G2H6
- Every structure of UniProt I7FPH1
- Every structure of UniProt I7FGS8
- Every structure of UniProt I7GD61
- Elsewhere: RCSB PDB 7RH7 · PDBe 7RH7 · UniProt I7GFE1 · UniProt I7GD63 · UniProt A0R049 · UniProt I7FPH7 · UniProt I7FQK8 · UniProt A0R1B5 · UniProt A0QVH4 · UniProt I7G2H6 · UniProt I7FPH1 · UniProt I7FGS8 · UniProt I7GD61
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