HUU · 6-chloranyl-2-ethyl-N-[[4-[4-[4-(trifluoromethyloxy) phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide

Binding sites

HUU in 4 structures; the first of them:

• 7E1W · Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium… · HUU N609 · binds PHE158, TYR161, TYR164, LEU171, GLY175, ALA179, LEU180, ILE183 and 14 more
• 7RH7 · Mycobacterial CIII2CIV2 supercomplex, Telacebec (Q203) bound · HUU E603 · binds PHE153, PHE156, TYR159, LEU166, SER167, THR169, GLY170, ALA173 and 17 more
• 7E1W · Cryo-EM structure of hybrid respiratory supercomplex consisting of mycobacterium… · HUU N609 · binds TYR161, LEU171, GLY175, ALA179, LEU180, ILE183, THR184, MET187 and 10 more
• 7RH7 · Mycobacterial CIII2CIV2 supercomplex, telacebec (Q203) bound · HUU E603 · binds PHE153, PHE156, TYR159, LEU166, GLY170, ALA173, ALA174, ILE178 and 12 more

Residues it binds most

MET 8, LEU 8, ALA 8, THR 8, ILE 8, PHE 7, TYR 8, SER 8, GLN 8, GLY 8 (residue and the binding sites it lines).

Found with

• 9Y0 · (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate
• 9YF · (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1r,2r,3r,4r, 5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate
• CDL · Cardiolipin
• FES · Fe2/s2 (inorganic) cluster
• HEA · Heme-A
• HEC · Heme C
• HEM · Protoporphyrin IX containing Fe
• MQ9 · Menaquinone-9
• PLM · Palmitic acid
• CU · Copper (II) ion
• 9XX · (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate