MolNFT v1 · #185962 · protein
Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with GABA, histamine and nanobody NB25
7QN7: “Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with GABA…”. Electron microscopy, 8 ligands (D10, R16, HSM). MolNFT v1 #185962 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7QN7
- Type
- protein
- Length
- 1,881 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P48169, P28472, O14764
- Ligands
- D10, R16, HSM, PX6, ABU, NAG, MAN, BMA
Structure
electron microscopy · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 335 | — | P48169 |
| B, C, D | — | protein | 327 | — | P28472 |
| E | — | protein | 323 | — | O14764 |
| F, G | — | protein | 121 | — | — |
Ligands and binding sites
- D10 · Decane · ligand · 4 copies · chains A, B, D, E
- R16 · Hexadecane · ligand · 2 copies · chains B, C
- HSM · Histamine · ligand · 2 copies · chains B, C, D
- PX6 · 1,2-dipalmitoyl-sn-glycero-3-phosphate · ligand · chains A
- ABU · Gamma-amino-butanoic acid · ligand · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 20 copies · chains A, B, C, F, D, G, E
- MAN · alpha-D-mannopyranose · sugar · 8 copies · chains C, B, F
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7QN7 · Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex… · the same entry in another collection · chain G against G, TM-score 1.00
- P28472 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-3… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P48169 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-4… · a predicted model of the same protein · chain A against A, TM-score 0.99
- O14764 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit delta… · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48169
- Every structure of UniProt P28472
- Every structure of UniProt O14764
- Elsewhere: RCSB PDB 7QN7 · PDBe 7QN7 · UniProt P48169 · UniProt P28472 · UniProt O14764
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