UniProt P48169
Gamma-aminobutyric acid receptor subunit alpha-4 (P48169)
Gamma-aminobutyric acid receptor subunit alpha-4 (UniProt P48169): 7 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P48169
- Protein
- Gamma-aminobutyric acid receptor subunit alpha-4
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 16 · 2 records with a druggable one
Structures
8 records of P48169 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7QN5 | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with… | electron microscopy | A | NAG, PX6, D10 | 9 (best 0.83) |
| 7QN5 | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with… | electron microscopy | A | NAG, PX6, D10 | — |
| 7QN7 | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with… | electron microscopy | A | NAG, PX6, D10, ABU | 7 (best 0.81) |
| 7QN7 | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with… | electron microscopy | A | NAG, PX6, D10, ABU | — |
| 7QN9 | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with… | electron microscopy | A | NAG, HSM | — |
| 7QNA | Cryo-EM structure of human full-length ALPHA4BETA3GAMMA2 GABA(A)R in complex with GABA and nanobody… | electron microscopy | A | NAG, ABU | — |
| 7QNC | Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with thip… | electron microscopy | A | NAG, EI7 | — |
| P48169 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-4 (P48169) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7QNA chain A against the predicted model P48169: TM-score 0.99, RMSD 0.72 Å
- 7QN7 chain A against the predicted model P48169: TM-score 0.99, RMSD 0.83 Å
- 7QN7 chain A against the predicted model P48169: TM-score 0.99, RMSD 0.83 Å
- 7QNC chain A against the predicted model P48169: TM-score 0.98, RMSD 0.85 Å
- 7QN5 chain A against the predicted model P48169: TM-score 0.98, RMSD 0.85 Å
- 7QN5 chain A against the predicted model P48169: TM-score 0.98, RMSD 0.85 Å
- 7QN9 chain A against the predicted model P48169: TM-score 0.98, RMSD 1.01 Å
Elsewhere
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