MolNFT v1 · #185965 · protein
Cryo-EM structure of human full-length ALPHA4BETA3GAMMA2 GABA(A)R in complex with GABA and nanobody NB25
7QNA: “Cryo-EM structure of human full-length ALPHA4BETA3GAMMA2 GABA(A)R in complex with GABA and nanobody NB25”. Electron microscopy, 4 ligands (ABU, NAG, MAN). MolNFT v1 #185965 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7QNA
- Type
- protein
- Length
- 1,763 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P48169, P28472, A0A1W2PQX1
- Ligands
- ABU, NAG, MAN, BMA
Structure
electron microscopy · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 333 | — | P48169 |
| B, D, E | — | protein | 327 | — | P28472 |
| C | — | protein | 328 | — | A0A1W2PQX1 |
| N | — | protein | 121 | — | — |
Ligands and binding sites
- ABU · Gamma-amino-butanoic acid · ligand · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 16 copies · chains A, B, D, E, N, C
- MAN · alpha-D-mannopyranose · sugar · 8 copies · chains N
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains B, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7QNA · Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA… · the same entry in another collection · chain N against N, TM-score 1.00
- P28472 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-3… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P48169 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-4… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48169
- Every structure of UniProt P28472
- Every structure of UniProt A0A1W2PQX1
- Elsewhere: RCSB PDB 7QNA · PDBe 7QNA · UniProt P48169 · UniProt P28472 · UniProt A0A1W2PQX1
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