MolNFT v1 · #185074 · protein
Cryo-EM structure of deptor bound to human mtor complex 2, focussed on one protomer
7PE8: “Cryo-EM structure of deptor bound to human mtor complex 2, focussed on one protomer”. Electron microscopy, 3 ligands (IHP, ACE, ZN). MolNFT v1 #185074 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7PE8
- Type
- protein
- Length
- 3,832 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P42345, Q9BVC4, Q6R327, Q9BPZ7, Q8TB45
- Ligands
- IHP, ACE, ZN
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 2194 | — | P42345 |
| C | — | protein | 319 | — | Q9BVC4 |
| E | — | protein | 1115 | — | Q6R327 |
| G | — | protein | 98 | — | Q9BPZ7 |
| I | — | protein | 106 | — | Q8TB45 |
Ligands and binding sites
- IHP · Inositol hexakisphosphate · ligand · chains A
- ACE · Acetyl group · ligand · chains E, G
- ZN · Zinc ion · metal · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7PE8 · cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer · the same entry in another collection · chain I against I, TM-score 1.00
- Q9BVC4 · AlphaFold monomer V2.0 prediction for target of rapamycin complex subunit LST8 (Q9BVC4) · a predicted model of the same protein · chain C against A, TM-score 0.96
- Q6R327 · AlphaFold monomer V2.0 prediction for rapamycin-insensitive companion of mtor (Q6R327) · a predicted model of the same protein · chain E against A, TM-score 0.95
- Q8TB45 · AlphaFold monomer V2.0 prediction for dep domain-containing mtor- interacting protein… · a predicted model of the same protein · chain I against A, TM-score 0.91
- P42345 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase mtor (P42345) · a predicted model of the same protein · chain A against A, TM-score 0.87
- Q9BPZ7 · AlphaFold monomer V2.0 prediction for target of rapamycin complex 2 subunit MAPKAP1… · a predicted model of the same protein · chain G against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42345
- Every structure of UniProt Q9BVC4
- Every structure of UniProt Q6R327
- Every structure of UniProt Q9BPZ7
- Every structure of UniProt Q8TB45
- Elsewhere: RCSB PDB 7PE8 · PDBe 7PE8 · UniProt P42345 · UniProt Q9BVC4 · UniProt Q6R327 · UniProt Q9BPZ7 · UniProt Q8TB45
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