UniProt P42345
Serine/threonine-protein kinase mTOR (P42345)
Serine/threonine-protein kinase mTOR (UniProt P42345), EC 2.7.11.1: 68 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 137 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P42345
- Protein
- Serine/threonine-protein kinase mTOR
- EC
- 2.7.11.1
- Experimental structures
- 68
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 137 · 9 records with a druggable one
Structures
69 records of P42345 in the MolNFT archive: 68 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AUE | Fkbp-rapamycin binding domain (frb) of the fkbp-rapamycin associated protein | x-ray diffraction | A, B | — | — |
| 1AUE | Fkbp-rapamycin binding domain (frb) of the fkbp-rapamycin associated protein | x-ray diffraction | A, B | — | — |
| 1FAP | The structure of the immunophilin-immunosuppressant FKBP12-rapamycin complex interacting with human… | x-ray diffraction | B | — | — |
| 1FAP | The structure of the immunophilin-immunosuppressant FKBP12- rapamycin complex interacting with… | x-ray diffraction | B | — | — |
| 1NSG | The structure of the immunophilin-immunosuppressant FKBP12-rapamycin complex interacting with human… | x-ray diffraction | B | — | — |
| 1NSG | The structure of the immunophilin-immunosuppressant FKBP12-rapamycin complex interacting with human… | x-ray diffraction | B | — | — |
| 2FAP | The structure of the immunophilin-immunosuppressant FKBP12-(C16)-ethoxy rapamycin complex… | x-ray diffraction | B | — | — |
| 2FAP | The structure of the immunophilin-immunosuppressant FKBP12-(C16)- ethoxy rapamycin complex… | x-ray diffraction | B | — | — |
| 2GAQ | NMR SOLUTION STRUCTURE OF THE FRB DOMAIN OF mTOR | solution nmr | A | — | — |
| 2GAQ | NMR solution structure of the frb domain of mtor | solution nmr | A | — | — |
| 2NPU | The solution structure of the rapamycin-binding domain of mTOR (FRB) | solution nmr | A | — | — |
| 2NPU | The solution structure of the rapamycin-binding domain of mtor (frb) | solution nmr | A | — | — |
| 2RSE | NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS | solution nmr | B | — | — |
| 2RSE | NMR structure of FKBP12-mtor frb domain-rapamycin complex structure determined based on pcs | solution nmr | B | — | — |
| 3FAP | Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb domain of frap | x-ray diffraction | B | — | — |
| 3FAP | Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb domain of frap | x-ray diffraction | B | — | — |
| 3JBZ | Crystal structure of mTOR docked into EM map of dimeric ATM kinase | electron microscopy | A | — | — |
| 3JBZ | Crystal structure of mtor docked into EM MAP of dimeric atm kinase | electron microscopy | A | — | — |
| 4DRH | Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low… | x-ray diffraction | B, E | — | — |
| 4DRH | Co-crystal structure of the ppiase domain of FKBP51, rapamycin and the frb fragment of mtor at low… | x-ray diffraction | B, E | — | — |
| 4DRI | Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR | x-ray diffraction | B | — | — |
| 4DRI | Co-crystal structure of the ppiase domain of FKBP51, rapamycin and the frb fragment of mtor | x-ray diffraction | B | — | — |
| 4DRJ | o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR | x-ray diffraction | B | — | — |
| 4DRJ | O-crystal structure of the ppiase domain of FKBP52, rapamycin and the frb fragment of mtor | x-ray diffraction | B | — | — |
| 4FAP | Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb domain of frap | x-ray diffraction | B | — | — |
| 4FAP | Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb domain of frap | x-ray diffraction | B | — | — |
| 4JSN | structure of mTORdeltaN-mLST8 complex | x-ray diffraction | B, A | — | — |
| 4JSN | Structure of mtordeltan-MLST8 complex | x-ray diffraction | B, A | — | — |
| 4JSP | structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex | x-ray diffraction | B, A | — | — |
| 4JSP | Structure of mtordeltan-MLST8-atpgammas-mg complex | x-ray diffraction | B, A | — | — |
| 4JSV | mTOR kinase structure, mechanism and regulation. | x-ray diffraction | B, A | — | — |
| 4JSV | Mtor kinase structure, mechanism and regulation. | x-ray diffraction | B, A | — | — |
| 4JSX | structure of mTORDeltaN-mLST8-Torin2 complex | x-ray diffraction | B, A | — | — |
| 4JSX | Structure of mtordeltan-MLST8-TORIN2 complex | x-ray diffraction | B, A | — | — |
| 4JT5 | mTORdeltaN-mLST8-pp242 complex | x-ray diffraction | B, A | — | — |
| 4JT5 | Mtordeltan-MLST8-PP242 complex | x-ray diffraction | B, A | — | — |
| 4JT6 | structure of mTORDeltaN-mLST8-PI-103 complex | x-ray diffraction | B, A | — | — |
| 4JT6 | Structure of mtordeltan-MLST8-pi-103 complex | x-ray diffraction | B, A | — | — |
| 5FLC | Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction | electron microscopy | B, F | RAP | — |
| 5FLC | Architecture of human mtor complex 1 - 5.9 ångström reconstruction | electron microscopy | B, F | — | — |
| 5GPG | Co-crystal structure of the FK506 binding domain of human FKBP25, rapamycin and the frb domain of… | x-ray diffraction | B | — | — |
| 5H64 | Cryo-EM structure of MTORC1 | electron microscopy | A, a | — | — |
| 5WBH | Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1 | x-ray diffraction | A, B, C, D, E | — | 6 (best 0.60) |
| 5WBH | Structure of the frb domain of mtor bound to a substrate recruitment peptide of S6K1 | x-ray diffraction | A, B, C, D, E | — | — |
| 5WBU | Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex | x-ray diffraction | B, A | — | — |
| 5WBU | Crystal structure of MTOR(DELTAN)-MLST8-PRAS40(ALPHA-helix & beta- strand) complex | x-ray diffraction | B, A | — | — |
| 5WBY | Crystal structure of MTOR(DELTAN)-MLST8-PRAS40(BETA-strand) complex | x-ray diffraction | B, A | — | — |
| 5ZCS | 4.9 ångström cryo-EM structure of human mtor complex 2 | electron microscopy | A, B | — | — |
| 6M4U | Crystal structure of fkbp-frb T2098L mutant in complex with rapamycin | x-ray diffraction | B, F | RAP, ZN, CL | — |
| 6M4W | Crystal structure of mbp fused split fkbp-frb T2098L mutant in complex with rapamycin | x-ray diffraction | G, H, I | RAP | — |
| 6SB0 | Cryo-EM structure of MTORC1 bound to PRAS40-fused active RAGA/C gtpases | electron microscopy | A, B | — | — |
| 6SB2 | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | electron microscopy | A, B | — | 10 (best 0.86) |
| 6SB2 | Cryo-EM structure of MTORC1 bound to active RAGA/C gtpases | electron microscopy | A, B | — | — |
| 6ZWM | Cryo-EM structure of human mtor complex 2, overall refinement | electron microscopy | A, B | AGS, IHP | — |
| 6ZWO | Cryo-EM structure of human mtor complex 2, focused on one half | electron microscopy | B | AGS, IHP | — |
| 7OWG | Human deptor in a complex with mutant human MTORC1 A1459P | electron microscopy | B | — | — |
| 7PE7 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement | electron microscopy | B, A | IHP | 19 (best 0.85) |
| 7PE7 | Cryo-EM structure of deptor bound to human mtor complex 2, overall refinement | electron microscopy | B, A | IHP | — |
| 7PE8 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer | electron microscopy | A | IHP | 17 (best 0.83) |
| 7PE8 | Cryo-EM structure of deptor bound to human mtor complex 2, focussed on one protomer | electron microscopy | A | IHP | — |
9 records more on the page itself.
Ligands
- IHP · Inositol hexakisphosphate · in 11 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 3 records
- MG · Magnesium ion · in 3 records
- RAP · Rapamycin immunosuppressant drug · in 3 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records
- CL · Chloride ion · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 5WBH chain E against the predicted model P42345: TM-score 0.98, RMSD 0.46 Å
- 5WBH chain E against the predicted model P42345: TM-score 0.98, RMSD 0.46 Å
- 5WBH chain A against the predicted model P42345: TM-score 0.98, RMSD 0.46 Å
- 5WBH chain A against the predicted model P42345: TM-score 0.98, RMSD 0.46 Å
- 6M4W chain G against the predicted model P42345: TM-score 0.98, RMSD 0.51 Å
- 5WBH chain D against the predicted model P42345: TM-score 0.98, RMSD 0.55 Å
- 5WBH chain B against the predicted model P42345: TM-score 0.98, RMSD 0.56 Å
- 1AUE chain B against the predicted model P42345: TM-score 0.97, RMSD 0.58 Å
- 1AUE chain B against the predicted model P42345: TM-score 0.97, RMSD 0.58 Å
- 1NSG chain B against the predicted model P42345: TM-score 0.97, RMSD 0.66 Å
Elsewhere
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