UniProt Q9BPZ7
Target of rapamycin complex 2 subunit MAPKAP1 (Q9BPZ7)
Target of rapamycin complex 2 subunit MAPKAP1 (UniProt Q9BPZ7): 27 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 39 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9BPZ7
- Protein
- Target of rapamycin complex 2 subunit MAPKAP1
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 39 · 12 records with a druggable one
Structures
28 records of Q9BPZ7 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3VOQ | Crystal structure of the pleckstrin homology domain of human Sin1, a TORC2 subunit | x-ray diffraction | A, B | — | 2 (best 0.36) |
| 3VOQ | Crystal structure of the pleckstrin homology domain of human SIN1, a TORC2 subunit | x-ray diffraction | A, B | — | — |
| 5ZCS | 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | electron microscopy | G, H | — | — |
| 5ZCS | 4.9 ångström cryo-EM structure of human mtor complex 2 | electron microscopy | G, H | — | — |
| 6ZWM | cryo-EM structure of human mTOR complex 2, overall refinement | electron microscopy | G, H | ACE | 3 (best 0.82) |
| 6ZWM | Cryo-EM structure of human mtor complex 2, overall refinement | electron microscopy | G, H | ACE | — |
| 6ZWO | cryo-EM structure of human mTOR complex 2, focused on one half | electron microscopy | H | ACE | 1 (best 0.65) |
| 6ZWO | Cryo-EM structure of human mtor complex 2, focused on one half | electron microscopy | H | ACE | — |
| 7LC1 | Crystal Structure of KRAS4b (GMPPNP-bound) in complex with the RBD-PH domains of SIN1 | x-ray diffraction | B, D | — | 10 (best 0.68) |
| 7LC1 | Crystal structure of KRAS4B (gmppnp-bound) in complex with the rbd-pH domains of SIN1 | x-ray diffraction | B, D | — | — |
| 7LC2 | Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1 | x-ray diffraction | D, E | — | 5 (best 0.69) |
| 7LC2 | Crystal structure of KRAS4B-Q61R (gmppnp-bound) in complex with the RAS-binding domain (rbd) of SIN1 | x-ray diffraction | D, E | — | — |
| 7PE7 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement | electron microscopy | H, G | ACE | 2 (best 0.77) |
| 7PE7 | Cryo-EM structure of deptor bound to human mtor complex 2, overall refinement | electron microscopy | H, G | ACE | — |
| 7PE8 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer | electron microscopy | G | ACE | 1 (best 0.77) |
| 7PE8 | Cryo-EM structure of deptor bound to human mtor complex 2, focussed on one protomer | electron microscopy | G | ACE | — |
| 7PE9 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement | electron microscopy | G | ACE | 1 (best 0.76) |
| 7PE9 | Cryo-EM structure of deptor bound to human mtor complex 2, dept-bound subset local refinement | electron microscopy | G | ACE | — |
| 7TZO | The apo structure of human mTORC2 complex | electron microscopy | G, H | — | 3 (best 0.82) |
| 7VV8 | Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 | x-ray diffraction | C | — | 2 (best 0.65) |
| 7VV8 | Crystal structure of HRASQ61L(GMPPNP-bound) in complex with the RAS- binding DOMAIN(RBD) of SIN1 | x-ray diffraction | C | — | — |
| 7VV9 | Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 | x-ray diffraction | C | — | 2 (best 0.67) |
| 7VV9 | Crystal structure of HRAS(GMPPNP-bound) in complex with the RAS- binding DOMAIN(RBD) of SIN1 | x-ray diffraction | C | — | — |
| 7VVB | Crystal Structure of KRas4A(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 | x-ray diffraction | B | — | 1 (best 0.67) |
| 7VVB | Crystal structure of KRAS4A(GMPPNP-bound) in complex with the RAS- binding DOMAIN(RBD) of SIN1 | x-ray diffraction | B | — | — |
| 7VVG | Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 | x-ray diffraction | C | — | 2 (best 0.64) |
| 7VVG | Crystal structure of HRASG12V(GMPPNP-bound) in complex with the RAS- binding DOMAIN(RBD) of SIN1 | x-ray diffraction | C | — | — |
| Q9BPZ7 | AlphaFold monomer V2.0 prediction for target of rapamycin complex 2 subunit MAPKAP1 (Q9BPZ7) | predicted | A | — | 4 (best 0.44) |
Ligands
- ACE · Acetyl group · in 10 records
Experiment against prediction
- 7VVG chain C against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.90 Å
- 7VVG chain C against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.90 Å
- 7VV8 chain C against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.92 Å
- 7VV8 chain C against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.92 Å
- 7VVB chain B against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.92 Å
- 7VVB chain B against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.92 Å
- 7VV9 chain C against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.95 Å
- 7VV9 chain C against the predicted model Q9BPZ7: TM-score 0.94, RMSD 0.95 Å
- 3VOQ chain A against the predicted model Q9BPZ7: TM-score 0.92, RMSD 1.48 Å
- 3VOQ chain A against the predicted model Q9BPZ7: TM-score 0.92, RMSD 1.48 Å
Elsewhere
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