MolNFT v1 · #82488 · protein

Crystal structure of the pleckstrin homology domain of human SIN1, a TORC2 subunit

3VOQ · Target of rapamycin complex 2 subunit MAPKAP1: “Crystal structure of the pleckstrin homology domain of human SIN1, a TORC2 subunit”. X-ray diffraction, 2 pockets (best druggability 0.36). MolNFT v1 #82488 on GenesisL1: 3D structure…

PDB: 3VOQ
Type: protein
Length: 229 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Target of rapamycin complex 2 subunit MAPKAP1
UniProt: Q9BPZ7
Pockets: 2 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Target of rapamycin complex 2 subunit MAPKAP1	protein	116	24% helix, 48% strand	Q9BPZ7
B	Target of rapamycin complex 2 subunit MAPKAP1	protein	113	27% helix, 52% strand	Q9BPZ7

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.36	0.80	22	empty
2	67	0.35	0.76	22	empty

Interfaces

1 interface between chains.

A–B · 807 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

3VOQ · Crystal structure of the pleckstrin homology domain of human Sin1, a TORC2 subunit · the same entry in another collection · chain A against A, TM-score 1.00
Q9BPZ7 · AlphaFold monomer V2.0 prediction for target of rapamycin complex 2 subunit MAPKAP1… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BPZ7
Elsewhere: RCSB PDB 3VOQ · PDBe 3VOQ · UniProt Q9BPZ7

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