UniProt Q9BVC4
Target of rapamycin complex subunit LST8 (Q9BVC4)
Target of rapamycin complex subunit LST8 (UniProt Q9BVC4): 38 experimental structures and 1 predicted model on GenesisL1, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9BVC4
- Protein
- Target of rapamycin complex subunit LST8
- Experimental structures
- 38
- Predicted models
- 1
- Pockets
- 15 · 8 records with a druggable one
Structures
39 records of Q9BVC4 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4JSN | structure of mTORdeltaN-mLST8 complex | x-ray diffraction | D, C | — | — |
| 4JSN | Structure of mtordeltan-MLST8 complex | x-ray diffraction | D, C | — | — |
| 4JSP | structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex | x-ray diffraction | D, C | — | — |
| 4JSP | Structure of mtordeltan-MLST8-atpgammas-mg complex | x-ray diffraction | D, C | — | — |
| 4JSV | mTOR kinase structure, mechanism and regulation. | x-ray diffraction | D, C | — | — |
| 4JSV | Mtor kinase structure, mechanism and regulation. | x-ray diffraction | D, C | — | — |
| 4JSX | structure of mTORDeltaN-mLST8-Torin2 complex | x-ray diffraction | D, C | — | — |
| 4JSX | Structure of mtordeltan-MLST8-TORIN2 complex | x-ray diffraction | D, C | — | — |
| 4JT5 | mTORdeltaN-mLST8-pp242 complex | x-ray diffraction | D, C | — | — |
| 4JT5 | Mtordeltan-MLST8-PP242 complex | x-ray diffraction | D, C | — | — |
| 4JT6 | structure of mTORDeltaN-mLST8-PI-103 complex | x-ray diffraction | D, C | — | — |
| 4JT6 | Structure of mtordeltan-MLST8-pi-103 complex | x-ray diffraction | D, C | — | — |
| 5FLC | Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction | electron microscopy | D, H | — | — |
| 5FLC | Architecture of human mtor complex 1 - 5.9 ångström reconstruction | electron microscopy | D, H | — | — |
| 5H64 | Cryo-EM structure of MTORC1 | electron microscopy | C, c | — | — |
| 5WBU | Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex | x-ray diffraction | D, C | — | — |
| 5WBU | Crystal structure of MTOR(DELTAN)-MLST8-PRAS40(ALPHA-helix & beta- strand) complex | x-ray diffraction | D, C | — | — |
| 5WBY | Crystal structure of MTOR(DELTAN)-MLST8-PRAS40(BETA-strand) complex | x-ray diffraction | D, C | — | — |
| 5ZCS | 4.9 ångström cryo-EM structure of human mtor complex 2 | electron microscopy | C, D | — | — |
| 6SB0 | Cryo-EM structure of MTORC1 bound to PRAS40-fused active RAGA/C gtpases | electron microscopy | E, H | — | — |
| 6SB2 | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | electron microscopy | E, H | — | 2 (best 0.81) |
| 6SB2 | Cryo-EM structure of MTORC1 bound to active RAGA/C gtpases | electron microscopy | E, H | — | — |
| 6ZWM | cryo-EM structure of human mTOR complex 2, overall refinement | electron microscopy | C, D | — | 2 (best 0.84) |
| 6ZWM | Cryo-EM structure of human mtor complex 2, overall refinement | electron microscopy | C, D | — | — |
| 6ZWO | Cryo-EM structure of human mtor complex 2, focused on one half | electron microscopy | D | — | — |
| 7OWG | Human deptor in a complex with mutant human MTORC1 A1459P | electron microscopy | E | — | — |
| 7PE7 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement | electron microscopy | D, C | — | 2 (best 0.82) |
| 7PE7 | Cryo-EM structure of deptor bound to human mtor complex 2, overall refinement | electron microscopy | D, C | — | — |
| 7PE8 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer | electron microscopy | C | — | 1 (best 0.83) |
| 7PE8 | Cryo-EM structure of deptor bound to human mtor complex 2, focussed on one protomer | electron microscopy | C | — | — |
| 7PE9 | Cryo-EM structure of deptor bound to human mtor complex 2, dept-bound subset local refinement | electron microscopy | C | — | — |
| 7PEA | Cryo-EM structure of deptor bound to human mtor complex 1, overall refinement | electron microscopy | D, C | — | — |
| 7PEB | Cryo-EM structure of deptor bound to human mtor complex 1, focussed on one protomer | electron microscopy | C | — | — |
| 7PEC | cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement | electron microscopy | C | — | 2 (best 0.81) |
| 7PEC | Cryo-EM structure of deptor bound to human mtor complex 1, dept-bound subset local refinement | electron microscopy | C | — | — |
| 8RCH | CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in… | electron microscopy | D, E | — | 2 (best 0.83) |
| 8RCK | CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in… | electron microscopy | E | — | 2 (best 0.82) |
| 9F45 | cryo-EM structure of human LST2 bound to human mTOR complex 1 | electron microscopy | C, D | — | 2 (best 0.82) |
| Q9BVC4 | AlphaFold monomer V2.0 prediction for target of rapamycin complex subunit LST8 (Q9BVC4) | predicted | A | — | — |
Experiment against prediction
- 6SB2 chain E against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.14 Å
- 6SB2 chain E against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.14 Å
- 6SB2 chain H against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.14 Å
- 5WBY chain D against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.17 Å
- 5WBU chain D against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.17 Å
- 5WBU chain D against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.17 Å
- 9F45 chain D against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.17 Å
- 4JSN chain D against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.18 Å
- 4JSN chain D against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.18 Å
- 4JSP chain D against the predicted model Q9BVC4: TM-score 0.98, RMSD 1.19 Å
Elsewhere
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