UniProt Q6R327
Rapamycin-insensitive companion of mTOR (Q6R327)
Rapamycin-insensitive companion of mTOR (UniProt Q6R327): 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q6R327
- Protein
- Rapamycin-insensitive companion of mTOR
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 82 · 8 records with a druggable one
Structures
14 records of Q6R327 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZCS | 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | electron microscopy | E, F | — | 2 (best 0.85) |
| 5ZCS | 4.9 ångström cryo-EM structure of human mtor complex 2 | electron microscopy | E, F | — | — |
| 6ZWM | cryo-EM structure of human mTOR complex 2, overall refinement | electron microscopy | E, F | ZN, AGS, ACE | 10 (best 0.81) |
| 6ZWM | Cryo-EM structure of human mtor complex 2, overall refinement | electron microscopy | E, F | ZN, AGS, ACE | — |
| 6ZWO | cryo-EM structure of human mTOR complex 2, focused on one half | electron microscopy | F | ZN, AGS, ACE | 10 (best 0.78) |
| 6ZWO | Cryo-EM structure of human mtor complex 2, focused on one half | electron microscopy | F | ZN, AGS, ACE | — |
| 7PE7 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement | electron microscopy | F, E | ZN, ACE | 11 (best 0.85) |
| 7PE7 | Cryo-EM structure of deptor bound to human mtor complex 2, overall refinement | electron microscopy | F, E | ZN, ACE | — |
| 7PE8 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer | electron microscopy | E | ZN, ACE | 10 (best 0.77) |
| 7PE8 | Cryo-EM structure of deptor bound to human mtor complex 2, focussed on one protomer | electron microscopy | E | ZN, ACE | — |
| 7PE9 | cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement | electron microscopy | E | ZN, ACE | 8 (best 0.79) |
| 7PE9 | Cryo-EM structure of deptor bound to human mtor complex 2, dept-bound subset local refinement | electron microscopy | E | ZN, ACE | — |
| 7TZO | The apo structure of human mTORC2 complex | electron microscopy | E, F | — | 11 (best 0.85) |
| Q6R327 | AlphaFold monomer V2.0 prediction for rapamycin-insensitive companion of mtor (Q6R327) | predicted | A | — | 20 (best 0.80) |
Ligands
Experiment against prediction
- 6ZWO chain F against the predicted model Q6R327: TM-score 0.96, RMSD 2.07 Å
- 6ZWO chain F against the predicted model Q6R327: TM-score 0.96, RMSD 2.07 Å
- 6ZWM chain E against the predicted model Q6R327: TM-score 0.96, RMSD 2.14 Å
- 6ZWM chain E against the predicted model Q6R327: TM-score 0.96, RMSD 2.14 Å
- 7PE7 chain F against the predicted model Q6R327: TM-score 0.95, RMSD 2.22 Å
- 7PE7 chain F against the predicted model Q6R327: TM-score 0.95, RMSD 2.22 Å
- 7PE9 chain E against the predicted model Q6R327: TM-score 0.95, RMSD 2.14 Å
- 7PE9 chain E against the predicted model Q6R327: TM-score 0.95, RMSD 2.14 Å
- 7PE8 chain E against the predicted model Q6R327: TM-score 0.95, RMSD 2.25 Å
- 7PE8 chain E against the predicted model Q6R327: TM-score 0.95, RMSD 2.25 Å
Elsewhere
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