MolNFT v1 · #180987 · protein

Structure of human prestin in nanodisc in the presence of nacl

7LGW: “Structure of human prestin in nanodisc in the presence of nacl”. Electron microscopy, 6 ligands (D10, D12, HP6), 20 pockets (best druggability 0.85). MolNFT v1 #180987 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LGW
Type: protein
Length: 1,360 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prestin
UniProt: P58743
Ligands: D10, D12, HP6, C14, CLR, CL
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 64% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Prestin	protein	680	64% helix, 6% strand	P58743

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	907	0.85	0.87	77	empty
2	181	0.67	0.86	35	empty
3	179	0.66	0.86	34	empty
4	338	0.65	0.80	36	empty
5	377	0.65	0.79	40	empty

Interfaces

1 interface between chains.

A–B · 4017 Å² buried · 57 hydrogen bonds · protein-protein

Compared structures

7LGW · Structure of human Prestin in nanodisc in the presence of NaCl · the same entry in another collection · chain A against A, TM-score 1.00
P58743 · AlphaFold monomer V2.0 prediction for prestin (P58743) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P58743
Elsewhere: RCSB PDB 7LGW · PDBe 7LGW · UniProt P58743

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