The external aldimine form of the wild-type salmonella typhimurium tryptophan synthase at 1.80 ångström resolution with cesium ion at the metal coordination site

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 19% strand (DSSP).

Ligands and binding sites

• KOU · (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine · ligand · chains B
• CS · Cesium ion · metal · chains B
• CL · Chloride ion · ion · 2 copies · chains B
• EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
• DMS · Dimethyl sulfoxide · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1345 Ų buried · 30 hydrogen bonds · protein-protein

Compared structures

• 7L5H · The external aldimine form of the wild-type Salmonella typhimurium Tryptophan Synthase at… · the same entry in another collection · chain A against A, TM-score 1.00
• P0A2K1 · AlphaFold monomer V2.0 prediction for tryptophan synthase beta chain (P0A2K1) · a predicted model of the same protein · chain B against A, TM-score 1.00
• P00929 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P00929) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00929
• Every structure of UniProt P0A2K1
• Elsewhere: RCSB PDB 7L5H · PDBe 7L5H · UniProt P00929 · UniProt P0A2K1