UniProt P00929
Tryptophan synthase alpha chain (P00929)
Tryptophan synthase alpha chain (UniProt P00929), EC 4.2.1.20: 186 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 102 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P00929
- Protein
- Tryptophan synthase alpha chain
- EC
- 4.2.1.20
- Experimental structures
- 186
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 102 · 23 records with a druggable one
Structures
187 records of P00929 in the MolNFT archive: 186 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A50 | Crystal structure of wild-type tryptophan synthase complexed with 5-fluoroindole propanol phosphate | x-ray diffraction | A | — | — |
| 1A50 | Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol phosphate | x-ray diffraction | A | — | — |
| 1A5A | Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant… | x-ray diffraction | A | — | — |
| 1A5A | Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant… | x-ray diffraction | A | — | — |
| 1A5B | Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alpha… | x-ray diffraction | A | — | — |
| 1A5B | Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alpha… | x-ray diffraction | A | — | — |
| 1A5S | Crystal structure of wild-type tryptophan synthase complexed with 5-fluoroindole propanol phosphate… | x-ray diffraction | A | — | — |
| 1A5S | Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol… | x-ray diffraction | A | — | — |
| 1BEU | TRP synthase (D60N-ipp-ser) with K+ | x-ray diffraction | A | — | — |
| 1BEU | TRP synthase (D60N-ipp-ser) with K+ | x-ray diffraction | A | — | — |
| 1BKS | Tryptophan synthase (E.C.4.2.1.20) from salmonella typhimurium | x-ray diffraction | A | — | — |
| 1BKS | Tryptophan synthase (E.C.4.2.1.20) from salmonella typhimurium | x-ray diffraction | A | — | — |
| 1C29 | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1C29 | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1C8V | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1C8V | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1C9D | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1C9D | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1CW2 | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1CW2 | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1CX9 | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1CX9 | Crystal structure of the complex of bacterial tryptophan synthase with the transition state… | x-ray diffraction | A | — | — |
| 1FUY | Crystal structure of BETAA169L/BETAC170W double mutant of tryptophan synthase complexed with… | x-ray diffraction | A | — | — |
| 1FUY | Crystal structure of BETAA169L/BETAC170W double mutant of tryptophan synthase complexed with… | x-ray diffraction | A | — | — |
| 1K3U | Crystal structure of wild-type tryptophan synthase complexed with N-[1H-indol-3-yl-ACETYL]ASPARTIC… | x-ray diffraction | A | — | — |
| 1K3U | Crystal structure of wild-type tryptophan synthase complexed with N- [1H-indol-3-yl-ACETYL]ASPARTIC… | x-ray diffraction | A | — | — |
| 1K7E | Crystal structure of wild-type tryptophan synthase complexed with N-[1H-indol-3-yl-ACETYL]GLYCINE… | x-ray diffraction | A | — | — |
| 1K7E | Crystal structure of wild-type tryptophan synthase complexed with N- [1H-indol-3-yl-ACETYL]GLYCINE… | x-ray diffraction | A | — | — |
| 1K7F | Crystal structure of wild-type tryptophan synthase complexed with N-[1H-indol-3-yl-ACETYL]VALINE… | x-ray diffraction | A | — | — |
| 1K7F | Crystal structure of wild-type tryptophan synthase complexed with N- [1H-indol-3-yl-ACETYL]VALINE… | x-ray diffraction | A | — | — |
| 1K7X | Crystal structure of the beta-SER178PRO mutant of tryptophan synthase | x-ray diffraction | A | — | — |
| 1K7X | Crystal structure of the beta-SER178PRO mutant of tryptophan synthase | x-ray diffraction | A | — | — |
| 1K8X | Crystal Structure Of AlphaT183V Mutant Of Tryptophan Synthase From Salmonella Typhimurium | x-ray diffraction | A | — | — |
| 1K8X | Crystal structure of ALPHAT183V mutant of tryptophan synthase from salmonella typhimurium | x-ray diffraction | A | — | — |
| 1K8Y | Crystal structure of the tryptophan synthase beta-SER178PRO mutant complexed with… | x-ray diffraction | A | — | — |
| 1K8Y | Crystal structure of the tryptophan synthase beta-SER178PRO mutant complexed with… | x-ray diffraction | A | — | — |
| 1K8Z | Crystal structure of the tryptophan synthase beta-SER178PRO mutant complexed with… | x-ray diffraction | A | — | — |
| 1K8Z | Crystal structure of the tryptophan synthase beta-SER178PRO mutant complexed with… | x-ray diffraction | A | — | — |
| 1KFB | CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM WITH… | x-ray diffraction | A | — | — |
| 1KFB | Crystal structure of ALPHAT183V mutant of tryptophan synthase from salmonella typhimurium with… | x-ray diffraction | A | — | — |
| 1KFC | CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM With… | x-ray diffraction | A | — | — |
| 1KFC | Crystal structure of ALPHAT183V mutant of tryptophan synthase from salmonella typhimurium with… | x-ray diffraction | A | — | — |
| 1KFE | CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM WITH… | x-ray diffraction | A | — | — |
| 1KFE | Crystal structure of ALPHAT183V mutant of tryptophan synthase from salmonella typhimurium with… | x-ray diffraction | A | — | — |
| 1KFJ | Crystal structure of wild-type tryptophan synthase complexed with L-serine | x-ray diffraction | A | — | — |
| 1KFJ | Crystal structure of wild-type tryptophan synthase complexed with L-serine | x-ray diffraction | A | — | — |
| 1KFK | Crystal structure of Tryptophan Synthase From Salmonella Typhimurium | x-ray diffraction | A | — | — |
| 1KFK | Crystal structure of tryptophan synthase from salmonella typhimurium | x-ray diffraction | A | — | — |
| 1QOP | Crystal structure of wild-type tryptophan synthase complexed with indole propanol phosphate | x-ray diffraction | A | — | — |
| 1QOP | Crystal structure of wild-type tryptophan synthase complexed with indole propanol phosphate | x-ray diffraction | A | — | — |
| 1QOQ | Crystal structure of wild-type tryptophan synthase complexed with indole glycerol phosphate | x-ray diffraction | A | — | — |
| 1QOQ | Crystal structure of wild-type tryptophan synthase complexed with indole glycerol phosphate | x-ray diffraction | A | — | — |
| 1TJP | Crystal Structure Of Wild-Type Tryptophan Synthase Complexed With… | x-ray diffraction | A | — | — |
| 1TJP | Crystal structure of wild-type tryptophan synthase complexed with 1… | x-ray diffraction | A | — | — |
| 1TTP | Tryptophan synthase (E.C.4.2.1.20) in the presence of cesium, room temperature | x-ray diffraction | A | — | — |
| 1TTP | Tryptophan synthase (E.C.4.2.1.20) in the presence of cesium, room temperature | x-ray diffraction | A | — | — |
| 1TTQ | Tryptophan synthase (E.C.4.2.1.20) in the presence of potassium at room temperature | x-ray diffraction | A | — | — |
| 1TTQ | Tryptophan synthase (E.C.4.2.1.20) in the presence of potassium at room temperature | x-ray diffraction | A | — | — |
| 1UBS | Tryptophan synthase (E.C.4.2.1.20) with a mutation of lys 87->thr in the B subunit and in the… | x-ray diffraction | A | — | — |
| 1UBS | Tryptophan synthase (E.C.4.2.1.20) with a mutation of lys 87->thr in the B subunit and in the… | x-ray diffraction | A | — | — |
127 records more on the page itself.
Ligands
- CL · Chloride ion · in 40 records
- F9F · 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate · in 30 records
- CS · Cesium ion · in 19 records
- F6F · 2-{[4-(trifluoromethoxy)benzoyl]amino}ethyl dihydrogen phosphate · in 7 records
- 2AF · 2-aminophenol · in 2 records
- BZI · Benzimidazole · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 2CLM chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
- 2CLM chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
- 2CLF chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
- 2CLF chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
- 2CLH chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
- 2CLH chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
- 2CLI chain A against the predicted model P00929: TM-score 1.00, RMSD 0.41 Å
- 2CLI chain A against the predicted model P00929: TM-score 1.00, RMSD 0.41 Å
- 2CLE chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
- 2CLE chain A against the predicted model P00929: TM-score 1.00, RMSD 0.40 Å
Elsewhere
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