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Ligand · IGP

IGP · Indole-3-glycerol phosphate

IGP, Indole-3-glycerol phosphate (C11 H14 N O6 P, 287.2 g/mol), in the MolNFT structures on GenesisL1: bound in 14 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
IGP
Formula
C11 H14 N O6 P
Class
ligand
Structures
14
PDB entries
7

Binding sites

IGP in 14 structures; the first of them:

  • 1A53 · Complex of indole-3-glycerolphosphate synthase from sulfolobus solfataricus with… · IGP A300 · binds GLU51, LYS53, LEU83, PHE89, LYS110, PHE112, LEU131, ILE133 and 11 more
  • 1A5B · Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant… · IGP A271 · binds PHE22, GLU49, ALA59, ASN60, ILE64, LEU100, TYR102, ALA129 and 10 more
  • 1KFB · CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM… · IGP A550 · binds PHE22, GLU49, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129 and 9 more
  • 1QOQ · Crystal structure of wild-type tryptophan synthase complexed with indole glycerol… · IGP A300 · binds PHE22, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129, ILE153 and 8 more
  • 2RH9 · Tryptophan synthase complexed with IGP, internal aldimine, pH 9.0 · IGP A269 · binds PHE22, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129, ILE153 and 8 more
  • 2RHG · Tryptophan synthase complexed with IGP, pH 7.0, internal aldimine · IGP A269 · binds PHE22, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129, ILE153 and 8 more
  • 3T44 · Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS)… · IGP A300 · binds GLU57, LYS59, VAL92, PHE98, LYS119, PHE121, LEU140, ILE142 and 11 more
  • 1A53 · Complex of indole-3-glycerolphosphate synthase from sulfolobus solfataricus with… · IGP A300 · binds GLU51, LYS53, LEU83, PHE89, LYS110, PHE112, LEU131, ILE133 and 11 more
  • 1A5B · Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant… · IGP A271 · binds PHE22, GLU49, ALA59, ASN60, ILE64, LEU100, TYR102, ALA129 and 10 more
  • 1KFB · Crystal structure of ALPHAT183V mutant of tryptophan synthase from salmonella typhimurium… · IGP A550 · binds PHE22, GLU49, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129 and 9 more
  • 1QOQ · Crystal structure of wild-type tryptophan synthase complexed with indole glycerol… · IGP A300 · binds PHE22, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129, ILE153 and 8 more
  • 2RH9 · Tryptophan synthase complexed with igp, internal aldimine, pH 9.0 · IGP A269 · binds PHE22, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129, ILE153 and 8 more
  • 2RHG · Tryptophan synthase complexed with igp, pH 7.0, internal aldimine · IGP A269 · binds PHE22, ALA59, ASP60, ILE64, LEU100, TYR102, ALA129, ILE153 and 8 more
  • 3T44 · Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps)… · IGP A300 · binds GLU57, LYS59, VAL92, PHE98, LYS119, PHE121, LEU140, ILE142 and 11 more

Residues it binds most

ILE 14, GLY 14, PHE 14, SER 14, LEU 14, ALA 10, TYR 10, GLU 8, ASP 8, LYS 4 (residue and the binding sites it lines).

Found with

  • PLP · Pyridoxal-5'-phosphate
  • NA · Sodium ion
  • BE2 · 2-aminobenzoic acid
  • K · Potassium ion

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