MolNFT v1 · #50411 · protein
Tryptophan synthase complexed with igp, pH 7.0, internal aldimine
2RHG · Tryptophan synthase alpha chain: “Tryptophan synthase complexed with igp, pH 7.0, internal aldimine”. X-ray diffraction, 3 ligands (IGP, PLP, NA), 7 pockets (best druggability 0.71). MolNFT v1 #50411 on GenesisL1: 3D structure…
- PDB
- 2RHG
- Type
- protein
- Length
- 614 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan synthase alpha chain; Tryptophan synthase beta chain
- EC
- 4.2.1.20
- UniProt
- P00929, P0A2K1
- Ligands
- IGP, PLP, NA
- Pockets
- 7 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan synthase alpha chain (EC 4.2.1.20) | protein | 250 | 52% helix, 14% strand | P00929 |
| B | Tryptophan synthase beta chain (EC 4.2.1.20) | protein | 364 | 45% helix, 21% strand | P0A2K1 |
Ligands and binding sites
- IGP · Indole-3-glycerol phosphate · ligand · chains A
- PLP · Pyridoxal-5'-phosphate · ligand · chains B
- NA · Sodium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 532 | 0.71 | 0.80 | 63 | PLP |
| 2 | 301 | 0.68 | 0.82 | 33 | IGP |
| 3 | 78 | 0.39 | 0.78 | 17 | empty |
| 4 | 68 | 0.35 | 0.77 | 18 | empty |
| 5 | 50 | 0.31 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1122 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 2RHG · Tryptophan synthase complexed with IGP, pH 7.0, internal aldimine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00929
- Every structure of UniProt P0A2K1
- Elsewhere: RCSB PDB 2RHG · PDBe 2RHG · UniProt P00929 · UniProt P0A2K1
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