MolNFT v1 · #79467 · protein
Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with indole glycerol phosphate (igp) amd anthranilate
3T44 · Indole-3-glycerol phosphate synthase: “Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with…”. X-ray diffraction, 2 ligands (IGP, BE2), 1 pocket (best druggability 0.76). MolNFT…
- PDB
- 3T44
- Type
- protein
- Length
- 259 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Indole-3-glycerol phosphate synthase
- EC
- 4.1.1.48
- UniProt
- P0A632
- Ligands
- IGP, BE2
- Pockets
- 1 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Indole-3-glycerol phosphate synthase (EC 4.1.1.48) | protein | 259 | 47% helix, 18% strand | P0A632 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.76 | 0.92 | 32 | IGP, BE2 |
Compared structures
- 3T44 · Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A632
- Elsewhere: RCSB PDB 3T44 · PDBe 3T44 · UniProt P0A632
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