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Ligand · KOU

KOU · (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine

KOU, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine (C11 H15 N2 O8 P, 334.2 g/mol), in the MolNFT structures on GenesisL1: bound in 7 records (7 PDB entries). Every binding site with its residues…

Component
KOU
Formula
C11 H15 N2 O8 P
Class
ligand
Structures
7
PDB entries
7

Binding sites

KOU in 7 structures; the first of them:

  • 6DZ4 · Crystal structure of Salmonella typhimurium Tryptophan Synthase with sodium ion at the… · KOU B401 · binds ALA85, HIS86, LYS87, THR110, GLY111, ALA112, GLY113, GLN114 and 20 more
  • 6DZO · Crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-Q114A with… · KOU B408 · binds ALA85, HIS86, LYS87, GLU109, THR110, GLY111, ALA112, GLY113 and 20 more
  • 6WDU · The external aldimine form of the Salmonella thypi wild-type tryptophan synthase in open… · KOU B410 · binds ALA85, HIS86, LYS87, GLU109, THR110, GLY111, ALA112, GLY113 and 21 more
  • 7JQW · The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase… · KOU B415 · binds ALA85, HIS86, LYS87, THR110, GLY111, ALA112, GLY113, GLN114 and 19 more
  • 7KI7 · The external aldimine crystal structure of the beta-K167T mutant Tryptophan Synthase at… · KOU B403 · binds ALA85, HIS86, LYS87, THR110, GLY111, ALA112, GLY113, GLN114 and 19 more
  • 7L5H · The external aldimine form of the wild-type Salmonella typhimurium Tryptophan Synthase at… · KOU B403 · binds ALA85, HIS86, LYS87, GLU109, THR110, GLY111, ALA112, GLY113 and 20 more
  • 9BOW · X-ray structure of Thermus thermophilus serine hydroxymethyltransferase with PLP-L-Ser… · KOU B501 · binds TYR51, GLU53, TYR61, GLY257, GLY258, SER31, SER93, GLY94 and 14 more

Residues it binds most

GLY 7, ALA 7, HIS 7, SER 7, THR 7, LEU 6, LYS 7, GLU 7, ASN 7, CYS 6 (residue and the binding sites it lines).

Found with

  • DMS · Dimethyl sulfoxide
  • CL · Chloride ion
  • EDO · 1,2-ethanediol
  • CS · Cesium ion
  • F9F · 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate
  • SER · Serine
  • NA · Sodium ion
  • PEG · Di(hydroxyethyl)ether
  • 2AF · 2-aminophenol
  • FFO · N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
  • SO4 · Sulfate ion

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