MolNFT v1 · #179068 · protein
C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside
7JUD · Macrophage mannose receptor 1: “C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside”. X-ray diffraction, 2 ligands (MMA, CA), 1 pocket (best druggability 0.64). MolNFT v1 #179068 on…
- PDB
- 7JUD
- Type
- protein
- Length
- 254 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage mannose receptor 1
- UniProt
- P22897
- Ligands
- MMA, CA
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage mannose receptor 1 | protein | 122 | 24% helix, 28% strand | P22897 |
| B | Macrophage mannose receptor 1 | protein | 132 | 20% helix, 27% strand | P22897 |
Ligands and binding sites
- MMA · methyl alpha-D-mannopyranoside · sugar · 2 copies · chains A, B
- CA · Calcium ion · metal · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 439 | 0.64 | 0.77 | 57 | empty |
Interfaces
1 interface between chains.
- A–B · 350 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7JUD · C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- P22897 · AlphaFold monomer V2.0 prediction for macrophage mannose receptor 1 (P22897) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22897
- Elsewhere: RCSB PDB 7JUD · PDBe 7JUD · UniProt P22897
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