MolNFT v1 · #243893 · protein
AlphaFold monomer V2.0 prediction for macrophage mannose receptor 1 (P22897)
P22897: “AlphaFold monomer V2.0 prediction for macrophage mannose receptor 1 (P22897)”. 18 pockets (best druggability 0.82). MolNFT v1 #243893 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P22897
- Type
- protein
- Length
- 1,456 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf1770e5260EEBa91B7A9E674F368eD787DE8992D
- Molecule
- Macrophage mannose receptor 1
- UniProt
- P22897
- Pockets
- 18 · best druggability 0.82
Structure
1 distinct chain · 17% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage mannose receptor 1 | protein | 1456 | 17% helix, 28% strand | P22897 |
Pockets
18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 956 | 0.82 | 0.83 | 95 | empty |
| 2 | 908 | 0.78 | 0.81 | 109 | empty |
| 3 | 419 | 0.72 | 0.82 | 45 | empty |
| 4 | 636 | 0.67 | 0.76 | 60 | empty |
| 5 | 593 | 0.67 | 0.77 | 48 | empty |
Modifications
Observed in the structure: 26 disulfide (disulfide).
Compared structures
- 6INN · Crystal structure of the cysr-CTLD3 fragment of human mr at acidic pH (pH 5.6) · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 5XTS · Crystal structure of the cysr-CTLD3 fragment of human mr at BASIC/NEUTRAL pH · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 6INU · Crystal structure of the CysR-CTLD2 fragment of human MR at acidic pH (pH 4.6) · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 6INU · Crystal structure of the cysr-CTLD2 fragment of human mr at acidic pH (pH 4.6) · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 6IOE · Crystal structure of the CysR-CTLD2 fragment of human MR at basic pH (pH 8.5) · an experimental structure of the same protein · chain A against A, TM-score 0.30
- 6IOE · Crystal structure of the cysr-CTLD2 fragment of human mr at basic pH (pH 8.5) · an experimental structure of the same protein · chain A against A, TM-score 0.30
- 5XTW · Crystal structure of the cysr-CTLD2 fragment of human mr at acidic pH · an experimental structure of the same protein · chain A against E, TM-score 0.30
- 6INO · Crystal structure of the cysr-CTLD2 fragment of human mr at acidic pH (pH 4.6) · an experimental structure of the same protein · chain A against B, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22897
- Elsewhere: UniProt P22897 · AlphaFold DB P22897
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