MolNFT v1 · #152637 · protein
Crystal structure of the cysr-CTLD2 fragment of human mr at basic pH (pH 8.5)
6IOE · Macrophage mannose receptor 1: “Crystal structure of the cysr-CTLD2 fragment of human mr at basic pH (pH 8.5)”. X-ray diffraction, 5 pockets (best druggability 0.72). MolNFT v1 #152637 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6IOE
- Type
- protein
- Length
- 900 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage mannose receptor 1
- UniProt
- P22897
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage mannose receptor 1 | protein | 454 | 12% helix, 33% strand | P22897 |
| B | Macrophage mannose receptor 1 | protein | 446 | 12% helix, 30% strand | P22897 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 730 | 0.72 | 0.78 | 57 | empty |
| 2 | 77 | 0.41 | 0.79 | 16 | empty |
| 3 | 64 | 0.30 | 0.74 | 17 | empty |
| 4 | 57 | 0.29 | 0.75 | 17 | empty |
| 5 | 56 | 0.27 | 0.74 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 410 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 19 disulfide (disulfide).
Compared structures
- 6IOE · Crystal structure of the CysR-CTLD2 fragment of human MR at basic pH (pH 8.5) · the same entry in another collection · chain A against A, TM-score 1.00
- P22897 · AlphaFold monomer V2.0 prediction for macrophage mannose receptor 1 (P22897) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22897
- Elsewhere: RCSB PDB 6IOE · PDBe 6IOE · UniProt P22897
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