MolNFT v1 · #17718 · protein

Structure of a beta-TRCP1-SKP1-beta-catenin complex: destruction motif binding and lysine specificity on the scfbeta-TRCP1 ubiquitin ligase

1P22 · F-BOX/WD-repeat protein 1A: “Structure of a beta-TRCP1-SKP1-beta-catenin complex: destruction motif binding and lysine specificity on the…”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #17718 on GenesisL1: 3D…

PDB: 1P22
Type: protein
Length: 544 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: F-BOX/WD-repeat protein 1A; SKP1; Beta-catenin
UniProt: Q9Y297, P63208, P35222
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 3 distinct chains · 26% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	F-BOX/WD-repeat protein 1A	protein	402	20% helix, 36% strand	Q9Y297
B	SKP1	protein	131	49% helix, 9% strand	P63208
C	Beta-catenin	protein	11	0% helix, 18% strand	P35222

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	233	0.48	0.74	30	empty

Interfaces

2 interfaces between chains.

A–B · 1637 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 695 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (phosphorylation).

Compared structures

1P22 · Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine… · the same entry in another collection · chain B against B, TM-score 1.00
Q9Y297 · AlphaFold monomer V2.0 prediction for F-BOX/WD repeat-containing protein 1A (Q9Y297) · a predicted model of the same protein · chain A against A, TM-score 0.99
P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain B against A, TM-score 0.93
P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain C against A, TM-score 0.31

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y297
Every structure of UniProt P63208
Every structure of UniProt P35222
Elsewhere: RCSB PDB 1P22 · PDBe 1P22 · UniProt Q9Y297 · UniProt P63208 · UniProt P35222

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