UniProt Q9Y297
F-box/WD repeat-containing protein 1A (Q9Y297)
F-box/WD repeat-containing protein 1A (UniProt Q9Y297): 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y297
- Protein
- F-box/WD repeat-containing protein 1A
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 16 · 3 records with a druggable one
Structures
17 records of Q9Y297 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1P22 | Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine… | x-ray diffraction | A | — | 1 (best 0.48) |
| 1P22 | Structure of a beta-TRCP1-SKP1-beta-catenin complex: destruction motif binding and lysine… | x-ray diffraction | A | — | — |
| 2P64 | D domain of b-TrCP | x-ray diffraction | A, B | — | — |
| 2P64 | D domain of B-trcp | x-ray diffraction | A, B | — | — |
| 6M90 | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex | x-ray diffraction | A | J91, PO4 | 1 (best 0.52) |
| 6M90 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-2776 ternary complex | x-ray diffraction | A | J91, PO4 | — |
| 6M91 | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex | x-ray diffraction | A | J97, PO4 | 2 (best 0.46) |
| 6M91 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-103094 ternary complex | x-ray diffraction | A | J97, PO4 | — |
| 6M92 | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex | x-ray diffraction | A | J8V, PO4 | 3 (best 0.53) |
| 6M92 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-2663 ternary complex | x-ray diffraction | A | J8V, PO4 | — |
| 6M93 | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex | x-ray diffraction | A | J8Y, PO4 | 2 (best 0.40) |
| 6M93 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-1933 ternary complex | x-ray diffraction | A | J8Y, PO4 | — |
| 6M94 | Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex | x-ray diffraction | A | PO4 | 1 (best 0.50) |
| 6M94 | Monophosphorylated PSER33 B-catenin peptide bound to B-TRCP/SKP1 complex | x-ray diffraction | A | PO4 | — |
| 6TTU | Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1… | electron microscopy | T | — | 6 (best 0.71) |
| 6TTU | Ubiquitin ligation to substrate by a cullin-ring E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1… | electron microscopy | T | — | — |
| Q9Y297 | AlphaFold monomer V2.0 prediction for F-BOX/WD repeat-containing protein 1A (Q9Y297) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 10 records
- J8V · 3-{[2-oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid · in 2 records
- J8Y · 2-oxo-N-[3-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide · in 2 records
- J91 · 2-(2-fluorophenoxy)-3-{[2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid · in 2 records
- J97 · 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid · in 2 records
Experiment against prediction
- 6M90 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.65 Å
- 6M90 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.65 Å
- 6M91 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.67 Å
- 6M91 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.67 Å
- 6M92 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.66 Å
- 6M92 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.66 Å
- 6M94 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.67 Å
- 6M94 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.67 Å
- 6M93 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.72 Å
- 6M93 chain A against the predicted model Q9Y297: TM-score 0.99, RMSD 0.72 Å
Elsewhere
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