Research workbench
Structure of a beta-TRCP1-SKP1-beta-catenin complex: destruction motif binding and lysine specificity on the scfbeta-TRCP1 ubiquitin ligase
Analyse Structure of a beta-TRCP1-SKP1-beta-catenin complex: destruction motif binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1P22
- Type
- protein
- Length
- 544 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-BOX/WD-repeat protein 1A; SKP1; Beta-catenin
- UniProt
- Q9Y297, P63208, P35222
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-BOX/WD-repeat protein 1A | protein | 402 | 20% helix, 36% strand | Q9Y297 |
| B | SKP1 | protein | 131 | 49% helix, 9% strand | P63208 |
| C | Beta-catenin | protein | 11 | 0% helix, 18% strand | P35222 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.48 | 0.74 | 30 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1637 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 695 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 1P22 · Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9Y297 · AlphaFold monomer V2.0 prediction for F-BOX/WD repeat-containing protein 1A (Q9Y297) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain B against A, TM-score 0.93
- P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain C against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y297
- Every structure of UniProt P63208
- Every structure of UniProt P35222
- Elsewhere: RCSB PDB 1P22 · PDBe 1P22 · UniProt Q9Y297 · UniProt P63208 · UniProt P35222
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