UniProt P35222
Catenin beta-1 (P35222)
Catenin beta-1 (UniProt P35222): 54 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35222
- Protein
- Catenin beta-1
- Experimental structures
- 54
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 18 · 5 records with a druggable one
Structures
55 records of P35222 in the MolNFT archive: 54 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1G3J | Crystal structure of the XTCF3-CBD/BETA-catenin armadillo repeat complex | x-ray diffraction | A, C | — | — |
| 1G3J | Crystal structure of the XTCF3-CBD/BETA-catenin armadillo repeat complex | x-ray diffraction | A, C | — | — |
| 1JDH | Crystal structure of beta-catenin and htcf-4 | x-ray diffraction | A | — | — |
| 1JDH | Crystal structure of beta-catenin and htcf-4 | x-ray diffraction | A | — | — |
| 1JPW | Crystal Structure of a Human Tcf-4 / beta-Catenin Complex | x-ray diffraction | A, B, C | — | — |
| 1JPW | Crystal structure of a human tcf-4 / beta-catenin complex | x-ray diffraction | A, B, C | — | — |
| 1LUJ | Crystal Structure of the Beta-catenin/ICAT Complex | x-ray diffraction | A | — | — |
| 1LUJ | Crystal structure of the beta-CATENIN/ICAT complex | x-ray diffraction | A | — | — |
| 1P22 | Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine… | x-ray diffraction | C | — | — |
| 1P22 | Structure of a beta-TRCP1-SKP1-beta-catenin complex: destruction motif binding and lysine… | x-ray diffraction | C | — | — |
| 1QZ7 | Beta-catenin binding domain of Axin in complex with beta-catenin | x-ray diffraction | A | — | — |
| 1QZ7 | Beta-catenin binding domain of axin in complex with beta- catenin | x-ray diffraction | A | — | — |
| 1T08 | Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3 | x-ray diffraction | A | — | — |
| 1T08 | Crystal structure of beta-CATENIN/ICAT helical DOMAIN/UNPHOSPHORYLATED apc R3 | x-ray diffraction | A | — | — |
| 1TH1 | Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment | x-ray diffraction | A, B | — | — |
| 1TH1 | Beta-catenin in complex with a phosphorylated apc 20AA repeat fragment | x-ray diffraction | A, B | — | — |
| 2G57 | Structure of the Phosphorylation Motif of the oncogenic Protein beta-Catenin Recognized By a… | solution nmr | A | — | — |
| 2G57 | Structure of the phosphorylation motif of the oncogenic protein beta- catenin recognized by a… | solution nmr | A | — | — |
| 2GL7 | Crystal Structure of a beta-catenin/BCL9/Tcf4 complex | x-ray diffraction | A, D | — | — |
| 2GL7 | Crystal structure of a beta-CATENIN/BCL9/TCF4 complex | x-ray diffraction | A, D | — | — |
| 2Z6H | Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain | x-ray diffraction | A | — | — |
| 2Z6H | Crystal structure of beta-catenin armadillo repeat region and its C-terminal domain | x-ray diffraction | A | — | — |
| 3DIW | c-terminal beta-catenin bound TIP-1 structure | x-ray diffraction | C, D | — | — |
| 3DIW | C-terminal beta-catenin bound tip-1 structure | x-ray diffraction | C, D | — | — |
| 3SL9 | X-ray structure of Beta catenin in complex with Bcl9 | x-ray diffraction | A, B, E, G | — | — |
| 3SL9 | X-ray structure of beta catenin in complex with BCL9 | x-ray diffraction | A, B, E, G | — | — |
| 3SLA | X-ray structure of first four repeats of human beta-catenin | x-ray diffraction | A, B, C, D, E | — | — |
| 3SLA | X-ray structure of first four repeats of human beta-catenin | x-ray diffraction | A, B, C, D, E | — | — |
| 3TX7 | Crystal structure of LRH-1/beta-catenin complex | x-ray diffraction | A | — | — |
| 3TX7 | Crystal structure of lrh-1/BETA-catenin complex | x-ray diffraction | A | — | — |
| 4DJS | Structure of beta-catenin in complex with a stapled peptide inhibitor | x-ray diffraction | A | — | — |
| 4DJS | Structure of beta-catenin in complex with a stapled peptide inhibitor | x-ray diffraction | A | — | — |
| 6M90 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-2776 ternary complex | x-ray diffraction | C | J91 | — |
| 6M91 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-103094 ternary complex | x-ray diffraction | C | J97 | — |
| 6M92 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-2663 ternary complex | x-ray diffraction | C | J8V | — |
| 6M93 | Monophosphorylated PSER33 B-catenin peptide, B-TRCP/SKP1, nrx-1933 ternary complex | x-ray diffraction | C | J8Y | — |
| 6M94 | Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex | x-ray diffraction | C | — | — |
| 6M94 | Monophosphorylated PSER33 B-catenin peptide bound to B-TRCP/SKP1 complex | x-ray diffraction | C | — | — |
| 6O9B | Crystal structure of HLA-A3*01 in complex with a wild-type beta-catenin peptide | x-ray diffraction | C | — | — |
| 6O9B | Crystal structure of HLA-A3*01 in complex with a wild-type beta- catenin peptide | x-ray diffraction | C | — | — |
| 6O9C | Crystal structure of HLA-A3*01 in complex with a mutant beta-catenin peptide | x-ray diffraction | C | — | — |
| 6WLX | PAK4 kinase domain in complex with beta-catenin Ser675 substrate peptide | x-ray diffraction | B | — | 2 (best 0.59) |
| 6WLX | PAK4 kinase domain in complex with beta-catenin SER675 substrate peptide | x-ray diffraction | B | — | — |
| 6WNX | FBXW11-SKP1 in complex with a PSER33/PSER37 beta-catenin peptide | x-ray diffraction | C, F, I | — | — |
| 7AFW | Beta-Catenin in complex with compound 6 | x-ray diffraction | A | R9Q | — |
| 7AFW | Beta-catenin in complex with compound 6 | x-ray diffraction | A | R9Q | — |
| 7AR4 | Crystal structure of beta-catenin in complex with cyclic peptide inhibitor | x-ray diffraction | AAA | CL | 2 (best 0.60) |
| 7UWI | Structure of beta-catenin in complex with FP01567, a Helicon Polypeptide | x-ray diffraction | A | PO4 | 2 (best 0.33) |
| 8EI9 | Crystal structure of beta-catenin and the MDM2 p53-binding domain in complex with H332, a Helicon… | x-ray diffraction | A | WHL | 5 (best 0.57) |
| 8VMF | Crystal structure of a transition-state mimic of the GSK-3/Axin complex bound to a beta-catenin… | x-ray diffraction | C | — | 1 (best 0.74) |
| 8Y0G | Human beta-catenin crystal structure | x-ray diffraction | A | — | 1 (best 0.33) |
| 8Y0P | Beta-Catenin in complex with peptide 301 | x-ray diffraction | A, B | PRO | 3 (best 0.71) |
| 8Y14 | Beta-catenin Crystal Structure | x-ray diffraction | A | — | 1 (best 0.44) |
| 8Z5J | Beta-catenin Crystal Structure | x-ray diffraction | A | — | 1 (best 0.41) |
| P35222 | AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) | predicted | A | — | — |
Ligands
- R9Q · 3-[(2~{R})-4-methyl-5-oxidanylidene-2,3-dihydro-1,4-benzoxazepin-2-yl]benzenecarbonitrile · in 2 records
- CL · Chloride ion · in 1 record
- J8V · 3-{[2-oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid · in 1 record
- J8Y · 2-oxo-N-[3-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide · in 1 record
- J91 · 2-(2-fluorophenoxy)-3-{[2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid · in 1 record
- J97 · 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid · in 1 record
- PO4 · Phosphate ion · in 1 record
- PRO · Proline · in 1 record
- WHL · N,N'-(1,4-phenylene)diacetamide · in 1 record
Experiment against prediction
- 1G3J chain C against the predicted model P35222: TM-score 1.00, RMSD 0.46 Å
- 1G3J chain C against the predicted model P35222: TM-score 1.00, RMSD 0.46 Å
- 7AFW chain A against the predicted model P35222: TM-score 0.99, RMSD 0.39 Å
- 7AFW chain A against the predicted model P35222: TM-score 0.99, RMSD 0.39 Å
- 1TH1 chain A against the predicted model P35222: TM-score 0.99, RMSD 0.75 Å
- 1TH1 chain A against the predicted model P35222: TM-score 0.99, RMSD 0.75 Å
- 1JPW chain A against the predicted model P35222: TM-score 0.99, RMSD 0.76 Å
- 1JPW chain A against the predicted model P35222: TM-score 0.99, RMSD 0.76 Å
- 1JPW chain B against the predicted model P35222: TM-score 0.99, RMSD 0.79 Å
- 1JPW chain B against the predicted model P35222: TM-score 0.99, RMSD 0.79 Å
Elsewhere
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