MolNFT v1 · #176960 · protein
Serotonin 1E (5-HT1E) receptor-gi protein complex
7E33 · Guanine nucleotide-binding protein G(I) subunit alpha-1: “Serotonin 1E (5-HT1E) receptor-gi protein complex”. Electron microscopy, 1 ligand (HVU), 12 pockets (best druggability 0.81). MolNFT v1 #176960 on GenesisL1: 3D structure…
- PDB
- 7E33
- Type
- protein
- Length
- 1,086 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I) subunit alpha-1; Guanine nucleotide-binding…
- UniProt
- P63096, P62873, P59768, P28566
- Ligands
- HVU
- Pockets
- 12 · best druggability 0.81
Structure
electron microscopy · 5 distinct chains · 36% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 217 | 53% helix, 18% strand | P63096 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 333 | 6% helix, 44% strand | P62873 |
| E | SCFV16 | protein | 229 | 7% helix, 47% strand | — |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 50 | 52% helix, 0% strand | P59768 |
| R | Soluble cytochrome B562,5-hydroxytryptamine receptor 1E | protein | 257 | 82% helix, 0% strand | P28566 |
Ligands and binding sites
- HVU · 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 663 | 0.81 | 0.86 | 63 | empty |
| 2 | 377 | 0.78 | 0.87 | 38 | HVU |
| 3 | 954 | 0.76 | 0.79 | 94 | empty |
| 4 | 86 | 0.53 | 0.84 | 15 | empty |
| 5 | 129 | 0.50 | 0.80 | 26 | empty |
Interfaces
6 interfaces between chains.
- B–G · 2109 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1234 Ų buried · 18 hydrogen bonds · protein-protein
- A–R · 948 Ų buried · 4 hydrogen bonds · protein-protein
- A–E · 598 Ų buried · 13 hydrogen bonds · protein-protein
- B–E · 445 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7E33 · Serotonin 1E (5-HT1E) receptor-Gi protein complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P28566 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 1E (P28566) · a predicted model of the same protein · chain R against A, TM-score 0.93
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.89
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P28566
- Elsewhere: RCSB PDB 7E33 · PDBe 7E33 · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt P28566
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